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Nontrivial Replication of Loci Detected by Multi-Trait Methods. / Ning, Zheng; Tsepilov, Yakov A.; Sharapov, Sodbo Zh и др.

в: Frontiers in Genetics, Том 12, 627989, 03.02.2021.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Ning, Z, Tsepilov, YA, Sharapov, SZ, Wang, Z, Grishenko, AK, Feng, X, Shirali, M, Joshi, PK, Wilson, JF, Pawitan, Y, Haley, CS, Aulchenko, YS & Shen, X 2021, 'Nontrivial Replication of Loci Detected by Multi-Trait Methods', Frontiers in Genetics, Том. 12, 627989. https://doi.org/10.3389/fgene.2021.627989

APA

Ning, Z., Tsepilov, Y. A., Sharapov, S. Z., Wang, Z., Grishenko, A. K., Feng, X., Shirali, M., Joshi, P. K., Wilson, J. F., Pawitan, Y., Haley, C. S., Aulchenko, Y. S., & Shen, X. (2021). Nontrivial Replication of Loci Detected by Multi-Trait Methods. Frontiers in Genetics, 12, [627989]. https://doi.org/10.3389/fgene.2021.627989

Vancouver

Ning Z, Tsepilov YA, Sharapov SZ, Wang Z, Grishenko AK, Feng X и др. Nontrivial Replication of Loci Detected by Multi-Trait Methods. Frontiers in Genetics. 2021 февр. 3;12:627989. doi: 10.3389/fgene.2021.627989

Author

BibTeX

@article{e4235116499c4e4291dea99e382bd1e8,
title = "Nontrivial Replication of Loci Detected by Multi-Trait Methods",
abstract = "The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed. Most efforts have been made concerning improving GWAS discovery power. However, how to replicate these discovered pleiotropic loci has yet to be discussed thoroughly. Unlike a single-trait scenario, multi-trait replication is not trivial considering the underlying genotype-multi-phenotype map of the associations. Here, we evaluate four methods for replicating multi-trait associations, corresponding to four levels of replication strength. Weak replication cannot justify pleiotropic genetic effects, whereas strong replication using our developed correlation methods can inform consistent pleiotropic genetic effects across the discovery and replication samples. We provide a protocol for replicating multi-trait genetic associations in practice. The described methods are implemented in the free and open-source R package MultiABEL.",
keywords = "cross-phenotype association, genome-wide association study, genotype-phenotype map, multivariate analysis, pleiotropy, replication",
author = "Zheng Ning and Tsepilov, {Yakov A.} and Sharapov, {Sodbo Zh} and Zhipeng Wang and Grishenko, {Alexander K.} and Xiao Feng and Masoud Shirali and Joshi, {Peter K.} and Wilson, {James F.} and Yudi Pawitan and Haley, {Chris S.} and Aulchenko, {Yurii S.} and Xia Shen",
note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Ning, Tsepilov, Sharapov, Wang, Grishenko, Feng, Shirali, Joshi, Wilson, Pawitan, Haley, Aulchenko and Shen.",
year = "2021",
month = feb,
day = "3",
doi = "10.3389/fgene.2021.627989",
language = "English",
volume = "12",
journal = "Frontiers in Genetics",
issn = "1664-8021",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - Nontrivial Replication of Loci Detected by Multi-Trait Methods

AU - Ning, Zheng

AU - Tsepilov, Yakov A.

AU - Sharapov, Sodbo Zh

AU - Wang, Zhipeng

AU - Grishenko, Alexander K.

AU - Feng, Xiao

AU - Shirali, Masoud

AU - Joshi, Peter K.

AU - Wilson, James F.

AU - Pawitan, Yudi

AU - Haley, Chris S.

AU - Aulchenko, Yurii S.

AU - Shen, Xia

N1 - Publisher Copyright: © Copyright © 2021 Ning, Tsepilov, Sharapov, Wang, Grishenko, Feng, Shirali, Joshi, Wilson, Pawitan, Haley, Aulchenko and Shen.

PY - 2021/2/3

Y1 - 2021/2/3

N2 - The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed. Most efforts have been made concerning improving GWAS discovery power. However, how to replicate these discovered pleiotropic loci has yet to be discussed thoroughly. Unlike a single-trait scenario, multi-trait replication is not trivial considering the underlying genotype-multi-phenotype map of the associations. Here, we evaluate four methods for replicating multi-trait associations, corresponding to four levels of replication strength. Weak replication cannot justify pleiotropic genetic effects, whereas strong replication using our developed correlation methods can inform consistent pleiotropic genetic effects across the discovery and replication samples. We provide a protocol for replicating multi-trait genetic associations in practice. The described methods are implemented in the free and open-source R package MultiABEL.

AB - The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed. Most efforts have been made concerning improving GWAS discovery power. However, how to replicate these discovered pleiotropic loci has yet to be discussed thoroughly. Unlike a single-trait scenario, multi-trait replication is not trivial considering the underlying genotype-multi-phenotype map of the associations. Here, we evaluate four methods for replicating multi-trait associations, corresponding to four levels of replication strength. Weak replication cannot justify pleiotropic genetic effects, whereas strong replication using our developed correlation methods can inform consistent pleiotropic genetic effects across the discovery and replication samples. We provide a protocol for replicating multi-trait genetic associations in practice. The described methods are implemented in the free and open-source R package MultiABEL.

KW - cross-phenotype association

KW - genome-wide association study

KW - genotype-phenotype map

KW - multivariate analysis

KW - pleiotropy

KW - replication

UR - http://www.scopus.com/inward/record.url?scp=85101177734&partnerID=8YFLogxK

U2 - 10.3389/fgene.2021.627989

DO - 10.3389/fgene.2021.627989

M3 - Article

C2 - 33613642

AN - SCOPUS:85101177734

VL - 12

JO - Frontiers in Genetics

JF - Frontiers in Genetics

SN - 1664-8021

M1 - 627989

ER -

ID: 27966753