Standard

No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. / Bazhenova, Ekaterina Y.; Sinyakova, Nadezhda A.; Kulikova, Elizabeth A. и др.

в: Neuroscience Letters, Том 653, 13.07.2017, стр. 264-268.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Bazhenova, EY, Sinyakova, NA, Kulikova, EA, Kazarinova, IA, Bazovkina, DV, Gainetdinov, RR & Kulikov, AV 2017, 'No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice', Neuroscience Letters, Том. 653, стр. 264-268. https://doi.org/10.1016/j.neulet.2017.05.070

APA

Bazhenova, E. Y., Sinyakova, N. A., Kulikova, E. A., Kazarinova, I. A., Bazovkina, D. V., Gainetdinov, R. R., & Kulikov, A. V. (2017). No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience Letters, 653, 264-268. https://doi.org/10.1016/j.neulet.2017.05.070

Vancouver

Bazhenova EY, Sinyakova NA, Kulikova EA, Kazarinova IA, Bazovkina DV, Gainetdinov RR и др. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience Letters. 2017 июль 13;653:264-268. doi: 10.1016/j.neulet.2017.05.070

Author

Bazhenova, Ekaterina Y. ; Sinyakova, Nadezhda A. ; Kulikova, Elizabeth A. и др. / No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. в: Neuroscience Letters. 2017 ; Том 653. стр. 264-268.

BibTeX

@article{83e49a43ed8d4a90b2b9400b61cb022e,
title = "No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice",
abstract = "Selective serotonin reuptake inhibitors (SSRIs) are antidepressants that block serotonin transporter (SERT) and increase serotonin (5-HT) level in the synaptic cleft. The interaction between SERT and the key enzyme of 5-HT synthesis in the brain, tryptophan hydroxylase 2 (TPH2), is essential to maintain the brain 5-HT level. The G allele of C1473G polymorphism in Tph2 gene decreases enzyme activity by half in mouse brain. Here we studied effect of C1473G polymorphism on the reaction of brain 5-HT system to chronic fluoxetine treatment (120 mg/l in drinking water, for 3 weeks) in adult males of the congenic B6-1473C and B6-1473G mouse lines with high and low enzyme activity, respectively. The polymorphism did not affect the levels of 5-HT, its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) and Tph2 gene mRNA in the brain. Fluoxetine significantly attenuated 5-HT levels in the cortex and striatum, 5-HIAA concentrations in the cortex, hippocampus, striatum and midbrain, and Tph2 gene expression in the midbrain. However, we did not observed any effect of the genotype x treatment interaction on these neurochemical characteristics. Therefore, C1473G polymorphism does not seem to play an essential role in the reaction of the brain 5-HT system to chronic fluoxetine treatment.",
keywords = "C1473G polymorphism, Congenic mice, Fluoxetine, Serotonin, Tryptophan hydroxylase 2, HUMAN TRYPTOPHAN-HYDROXYLASE-2 GENE, TPH2 GENE, BEHAVIOR, ASSOCIATION, DEFICIENCY",
author = "Bazhenova, {Ekaterina Y.} and Sinyakova, {Nadezhda A.} and Kulikova, {Elizabeth A.} and Kazarinova, {Irina A.} and Bazovkina, {Daria V.} and Gainetdinov, {Raul R.} and Kulikov, {Alexander V.}",
note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",
year = "2017",
month = jul,
day = "13",
doi = "10.1016/j.neulet.2017.05.070",
language = "English",
volume = "653",
pages = "264--268",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice

AU - Bazhenova, Ekaterina Y.

AU - Sinyakova, Nadezhda A.

AU - Kulikova, Elizabeth A.

AU - Kazarinova, Irina A.

AU - Bazovkina, Daria V.

AU - Gainetdinov, Raul R.

AU - Kulikov, Alexander V.

N1 - Publisher Copyright: © 2017 Elsevier B.V.

PY - 2017/7/13

Y1 - 2017/7/13

N2 - Selective serotonin reuptake inhibitors (SSRIs) are antidepressants that block serotonin transporter (SERT) and increase serotonin (5-HT) level in the synaptic cleft. The interaction between SERT and the key enzyme of 5-HT synthesis in the brain, tryptophan hydroxylase 2 (TPH2), is essential to maintain the brain 5-HT level. The G allele of C1473G polymorphism in Tph2 gene decreases enzyme activity by half in mouse brain. Here we studied effect of C1473G polymorphism on the reaction of brain 5-HT system to chronic fluoxetine treatment (120 mg/l in drinking water, for 3 weeks) in adult males of the congenic B6-1473C and B6-1473G mouse lines with high and low enzyme activity, respectively. The polymorphism did not affect the levels of 5-HT, its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) and Tph2 gene mRNA in the brain. Fluoxetine significantly attenuated 5-HT levels in the cortex and striatum, 5-HIAA concentrations in the cortex, hippocampus, striatum and midbrain, and Tph2 gene expression in the midbrain. However, we did not observed any effect of the genotype x treatment interaction on these neurochemical characteristics. Therefore, C1473G polymorphism does not seem to play an essential role in the reaction of the brain 5-HT system to chronic fluoxetine treatment.

AB - Selective serotonin reuptake inhibitors (SSRIs) are antidepressants that block serotonin transporter (SERT) and increase serotonin (5-HT) level in the synaptic cleft. The interaction between SERT and the key enzyme of 5-HT synthesis in the brain, tryptophan hydroxylase 2 (TPH2), is essential to maintain the brain 5-HT level. The G allele of C1473G polymorphism in Tph2 gene decreases enzyme activity by half in mouse brain. Here we studied effect of C1473G polymorphism on the reaction of brain 5-HT system to chronic fluoxetine treatment (120 mg/l in drinking water, for 3 weeks) in adult males of the congenic B6-1473C and B6-1473G mouse lines with high and low enzyme activity, respectively. The polymorphism did not affect the levels of 5-HT, its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) and Tph2 gene mRNA in the brain. Fluoxetine significantly attenuated 5-HT levels in the cortex and striatum, 5-HIAA concentrations in the cortex, hippocampus, striatum and midbrain, and Tph2 gene expression in the midbrain. However, we did not observed any effect of the genotype x treatment interaction on these neurochemical characteristics. Therefore, C1473G polymorphism does not seem to play an essential role in the reaction of the brain 5-HT system to chronic fluoxetine treatment.

KW - C1473G polymorphism

KW - Congenic mice

KW - Fluoxetine

KW - Serotonin

KW - Tryptophan hydroxylase 2

KW - HUMAN TRYPTOPHAN-HYDROXYLASE-2 GENE

KW - TPH2 GENE

KW - BEHAVIOR

KW - ASSOCIATION

KW - DEFICIENCY

UR - http://www.scopus.com/inward/record.url?scp=85020262065&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2017.05.070

DO - 10.1016/j.neulet.2017.05.070

M3 - Article

AN - SCOPUS:85020262065

VL - 653

SP - 264

EP - 268

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -

ID: 9977395