TY - JOUR

T1 - New Ionic Conjugates Based on α-Tocopheryl Succinate as Potential Cytotoxic Agents

AU - Frolova, T. S.

AU - Sharapov, S. Z.

AU - Sinitsyna, O. I.

AU - Tolstikova, T. G.

AU - Grigoriev, I. A.

AU - Morozov, S. V.

AU - Yushkova, Y. V.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.

AB - Five new ionic conjugates based on α-tocopheryl succinate were synthesized, including amino- TEMPO, cytisine, convolvin, amantadine, and rimantadine as functional groups. Using bacterial test systems, the safety of the compounds obtained was shown, and antioxidant properties were studied. Investigation of the cytotoxic properties of synthesized conjugates with a chromane skeleton revealed their selectivity to the MCF7 breast cancer line, the effect was most pronounced for derivatives with amino-TEMPO and rimantadine fragments.

KW - antioxidants

KW - cytotoxicity

KW - ionic conjugates

KW - mitocans

KW - nitroxide radicals

KW - spin-labeled derivatives

KW - α-tocopheryl succinate

KW - VITAMIN-E

KW - ASSAY

KW - CANCER

KW - SOS CHROMOTEST

KW - alpha-tocopheryl succinate

KW - TROLOX

UR - http://www.scopus.com/inward/record.url?scp=85048556773&partnerID=8YFLogxK

U2 - 10.1134/S1068162018030068

DO - 10.1134/S1068162018030068

M3 - Article

AN - SCOPUS:85048556773

VL - 44

SP - 330

EP - 336

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

SN - 1068-1620

IS - 3

ER -