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Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds. / Cheplakova, Anastasia M.; Solovieva, Anastasiya O.; Pozmogova, Tatiana N. и др.

в: Journal of Inorganic Biochemistry, Том 166, 01.01.2017, стр. 100-107.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Cheplakova, AM, Solovieva, AO, Pozmogova, TN, Vorotnikov, YA, Brylev, KA, Vorotnikova, NA, Vorontsova, EV, Mironov, YV, Poveshchenko, AF, Kovalenko, KA & Shestopalov, MA 2017, 'Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds', Journal of Inorganic Biochemistry, Том. 166, стр. 100-107. https://doi.org/10.1016/j.jinorgbio.2016.11.014

APA

Cheplakova, A. M., Solovieva, A. O., Pozmogova, T. N., Vorotnikov, Y. A., Brylev, K. A., Vorotnikova, N. A., Vorontsova, E. V., Mironov, Y. V., Poveshchenko, A. F., Kovalenko, K. A., & Shestopalov, M. A. (2017). Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds. Journal of Inorganic Biochemistry, 166, 100-107. https://doi.org/10.1016/j.jinorgbio.2016.11.014

Vancouver

Cheplakova AM, Solovieva AO, Pozmogova TN, Vorotnikov YA, Brylev KA, Vorotnikova NA и др. Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds. Journal of Inorganic Biochemistry. 2017 янв. 1;166:100-107. doi: 10.1016/j.jinorgbio.2016.11.014

Author

Cheplakova, Anastasia M. ; Solovieva, Anastasiya O. ; Pozmogova, Tatiana N. и др. / Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds. в: Journal of Inorganic Biochemistry. 2017 ; Том 166. стр. 100-107.

BibTeX

@article{0d748c6fccb14fdfb821dd9e232aadb7,
title = "Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds",
abstract = "Inclusion compounds of photoluminescent hexamolybdenum cluster complexes in the chromium terephthalate metal-organic framework, MIL-101 (MIL, Mat{\'e}rial Institut Lavoisier) were successfully synthesized in two different ways and characterized by means of powder X-Ray diffraction, chemical analysis and nitrogen sorption. Some important functional properties of hexamolybdenum cluster complexes for biological and medical applications, in particular singlet oxygen generation ability, luminescence properties, cellular uptake behavior and cytotoxicity were studied. It was revealed that the inclusion compounds possessed significant singlet oxygen generation activity. The materials obtained showed a low cytotoxicity, thus allowing them to be used in living cells. Confocal microscopy of human larynx carcinoma (Hep-2) cells incubated with the inclusion compounds showed that MIL-101 performed as a nanocarrier adhering to the external cell membrane surface and releasing the cluster complexes which that penetrated into the cells. Moreover, photoinduced generation of reactive oxygen species (ROS) in Hep-2 cells incubated with inclusion compounds was demonstrated. The cluster supported on MIL-101 was shown to possess in vivo phototoxicity.",
keywords = "Hep-2 cells, Luminescence, MIL-101, Molybdenum clusters, Phototoxicity, Singlet oxygen, Reactive Oxygen Species/metabolism, Cell Line, Humans, Molybdenum/chemistry, Antineoplastic Agents/chemistry, Coordination Complexes/chemistry, Drug Carriers/chemistry, Laryngeal Neoplasms/drug therapy, HEXANUCLEAR MOLYBDENUM CLUSTERS, PHOTODYNAMIC THERAPY, DRUG-DELIVERY, COMPLEXES, ENCAPSULATION, LUMINESCENCE PROPERTIES, CHROMIUM(III) TEREPHTHALATE, SILICA NANOPARTICLES, CYTOTOXICITY, SORPTION PROPERTIES",
author = "Cheplakova, {Anastasia M.} and Solovieva, {Anastasiya O.} and Pozmogova, {Tatiana N.} and Vorotnikov, {Yuri A.} and Brylev, {Konstantin A.} and Vorotnikova, {Natalya A.} and Vorontsova, {Elena V.} and Mironov, {Yuri V.} and Poveshchenko, {Alexander F.} and Kovalenko, {Konstantin A.} and Shestopalov, {Michael A.}",
note = "Funding Information: The synthesis of new compounds, their characterization by analytical and physical methods in this work were supported by RF government (Grant No. 14.Z50.31.006 , leading scientist Martin Sсhr{\"o}der). Biological properties study was supported by the Russian Foundation for Basic Research (Grant No. 14-04-01816 ). M.A. Shestopalov acknowledges the grant of the President of the Russian Federation (grant number MK 4054.2015.3 ) for financial support. Y. A. Vorotnikov and K. A. Brylev gratefully thank Prof. N. Kitamura (Hokkaido University) for the opportunity to study the luminescence properties. This work involved the use of equipment from the Multi-Access Center “Proteomics” of the Institute of Molecular Biology and Biophysics (Novosibirsk, Russia). Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2017",
month = jan,
day = "1",
doi = "10.1016/j.jinorgbio.2016.11.014",
language = "English",
volume = "166",
pages = "100--107",
journal = "Journal of Inorganic Biochemistry",
issn = "0162-0134",
publisher = "Elsevier Science Inc.",

}

RIS

TY - JOUR

T1 - Nanosized mesoporous metal–organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds

AU - Cheplakova, Anastasia M.

AU - Solovieva, Anastasiya O.

AU - Pozmogova, Tatiana N.

AU - Vorotnikov, Yuri A.

AU - Brylev, Konstantin A.

AU - Vorotnikova, Natalya A.

AU - Vorontsova, Elena V.

AU - Mironov, Yuri V.

AU - Poveshchenko, Alexander F.

AU - Kovalenko, Konstantin A.

AU - Shestopalov, Michael A.

N1 - Funding Information: The synthesis of new compounds, their characterization by analytical and physical methods in this work were supported by RF government (Grant No. 14.Z50.31.006 , leading scientist Martin Sсhröder). Biological properties study was supported by the Russian Foundation for Basic Research (Grant No. 14-04-01816 ). M.A. Shestopalov acknowledges the grant of the President of the Russian Federation (grant number MK 4054.2015.3 ) for financial support. Y. A. Vorotnikov and K. A. Brylev gratefully thank Prof. N. Kitamura (Hokkaido University) for the opportunity to study the luminescence properties. This work involved the use of equipment from the Multi-Access Center “Proteomics” of the Institute of Molecular Biology and Biophysics (Novosibirsk, Russia). Publisher Copyright: © 2016 Elsevier Inc.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Inclusion compounds of photoluminescent hexamolybdenum cluster complexes in the chromium terephthalate metal-organic framework, MIL-101 (MIL, Matérial Institut Lavoisier) were successfully synthesized in two different ways and characterized by means of powder X-Ray diffraction, chemical analysis and nitrogen sorption. Some important functional properties of hexamolybdenum cluster complexes for biological and medical applications, in particular singlet oxygen generation ability, luminescence properties, cellular uptake behavior and cytotoxicity were studied. It was revealed that the inclusion compounds possessed significant singlet oxygen generation activity. The materials obtained showed a low cytotoxicity, thus allowing them to be used in living cells. Confocal microscopy of human larynx carcinoma (Hep-2) cells incubated with the inclusion compounds showed that MIL-101 performed as a nanocarrier adhering to the external cell membrane surface and releasing the cluster complexes which that penetrated into the cells. Moreover, photoinduced generation of reactive oxygen species (ROS) in Hep-2 cells incubated with inclusion compounds was demonstrated. The cluster supported on MIL-101 was shown to possess in vivo phototoxicity.

AB - Inclusion compounds of photoluminescent hexamolybdenum cluster complexes in the chromium terephthalate metal-organic framework, MIL-101 (MIL, Matérial Institut Lavoisier) were successfully synthesized in two different ways and characterized by means of powder X-Ray diffraction, chemical analysis and nitrogen sorption. Some important functional properties of hexamolybdenum cluster complexes for biological and medical applications, in particular singlet oxygen generation ability, luminescence properties, cellular uptake behavior and cytotoxicity were studied. It was revealed that the inclusion compounds possessed significant singlet oxygen generation activity. The materials obtained showed a low cytotoxicity, thus allowing them to be used in living cells. Confocal microscopy of human larynx carcinoma (Hep-2) cells incubated with the inclusion compounds showed that MIL-101 performed as a nanocarrier adhering to the external cell membrane surface and releasing the cluster complexes which that penetrated into the cells. Moreover, photoinduced generation of reactive oxygen species (ROS) in Hep-2 cells incubated with inclusion compounds was demonstrated. The cluster supported on MIL-101 was shown to possess in vivo phototoxicity.

KW - Hep-2 cells

KW - Luminescence

KW - MIL-101

KW - Molybdenum clusters

KW - Phototoxicity

KW - Singlet oxygen

KW - Reactive Oxygen Species/metabolism

KW - Cell Line

KW - Humans

KW - Molybdenum/chemistry

KW - Antineoplastic Agents/chemistry

KW - Coordination Complexes/chemistry

KW - Drug Carriers/chemistry

KW - Laryngeal Neoplasms/drug therapy

KW - HEXANUCLEAR MOLYBDENUM CLUSTERS

KW - PHOTODYNAMIC THERAPY

KW - DRUG-DELIVERY

KW - COMPLEXES

KW - ENCAPSULATION

KW - LUMINESCENCE PROPERTIES

KW - CHROMIUM(III) TEREPHTHALATE

KW - SILICA NANOPARTICLES

KW - CYTOTOXICITY

KW - SORPTION PROPERTIES

UR - http://www.scopus.com/inward/record.url?scp=84994758795&partnerID=8YFLogxK

U2 - 10.1016/j.jinorgbio.2016.11.014

DO - 10.1016/j.jinorgbio.2016.11.014

M3 - Article

C2 - 27842246

AN - SCOPUS:84994758795

VL - 166

SP - 100

EP - 107

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

SN - 0162-0134

ER -

ID: 10320465