Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy. / Filimonova, Elena; Ovsiannikov, Konstantin; Sosnov, Alexsey и др.
в: Frontiers in Neuroscience, Том 16, 982829, 23.08.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy
AU - Filimonova, Elena
AU - Ovsiannikov, Konstantin
AU - Sosnov, Alexsey
AU - Perfilyev, Artem
AU - Gafurov, Rustam
AU - Galaktionov, Dmitriy
AU - Bervickiy, Anatoliy
AU - Kiselev, Vitaly
AU - Rzaev, Jamil
N1 - Publisher Copyright: Copyright © 2022 Filimonova, Ovsiannikov, Sosnov, Perfilyev, Gafurov, Galaktionov, Bervickiy, Kiselev and Rzaev.
PY - 2022/8/23
Y1 - 2022/8/23
N2 - Background: Despite it being known that chronic ischemia results in myelin damage and gray matter atrophy, data regarding patients with moyamoya angiopathy is limited. We hypothesized that chronic ischemia in moyamoya angiopathy leads to myelin damage, especially in anterior watershed regions, as well as cortical atrophy in these areas. Materials and methods: Twenty adult patients with moyamoya angiopathy and 17 age- and sex-matched healthy controls were evaluated using the T1w/T2w mapping method and surface-based MR-morphometry. The T1w/T2w signal intensity ratio, which reflects the white matter integrity, and the cortical thickness, were calculated in watershed regions and compared between the patients and controls. In the patients with moyamoya angiopathy, the correlations between these parameters and the Suzuki stage were also evaluated. Results: The regional T1w/T2w ratio values from centrum semiovale in patients with MMA were significantly lower than those in healthy controls (p < 0.05); there was also a downward trend in T1w/T2w ratio values from middle frontal gyrus white matter in patients compared with the controls (p < 0.1). The cortical thickness of the middle frontal gyrus was significantly lower in patients than in healthy controls (p < 0.05). There were negative correlations between the Suzuki stage and the T1w/T2w ratio values from the centrum semiovale and middle frontal white matter. Conclusion: T1w/T2w mapping revealed that myelin damage exists in watershed regions in patients with moyamoya angiopathy, in association with cortical atrophy according to MR-morphometry. These changes were correlated with the disease stage.
AB - Background: Despite it being known that chronic ischemia results in myelin damage and gray matter atrophy, data regarding patients with moyamoya angiopathy is limited. We hypothesized that chronic ischemia in moyamoya angiopathy leads to myelin damage, especially in anterior watershed regions, as well as cortical atrophy in these areas. Materials and methods: Twenty adult patients with moyamoya angiopathy and 17 age- and sex-matched healthy controls were evaluated using the T1w/T2w mapping method and surface-based MR-morphometry. The T1w/T2w signal intensity ratio, which reflects the white matter integrity, and the cortical thickness, were calculated in watershed regions and compared between the patients and controls. In the patients with moyamoya angiopathy, the correlations between these parameters and the Suzuki stage were also evaluated. Results: The regional T1w/T2w ratio values from centrum semiovale in patients with MMA were significantly lower than those in healthy controls (p < 0.05); there was also a downward trend in T1w/T2w ratio values from middle frontal gyrus white matter in patients compared with the controls (p < 0.1). The cortical thickness of the middle frontal gyrus was significantly lower in patients than in healthy controls (p < 0.05). There were negative correlations between the Suzuki stage and the T1w/T2w ratio values from the centrum semiovale and middle frontal white matter. Conclusion: T1w/T2w mapping revealed that myelin damage exists in watershed regions in patients with moyamoya angiopathy, in association with cortical atrophy according to MR-morphometry. These changes were correlated with the disease stage.
KW - demyelination
KW - FreeSurfer
KW - magnetic resonance imaging (MRI)
KW - moyamoya angiopathy (MMA)
KW - MR-morphometry
KW - T1w/T2w ratio
UR - http://www.scopus.com/inward/record.url?scp=85137997659&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/a5c5f68a-2fb2-3250-a7bb-d05207bb4ce9/
U2 - 10.3389/fnins.2022.982829
DO - 10.3389/fnins.2022.982829
M3 - Article
C2 - 36081657
AN - SCOPUS:85137997659
VL - 16
JO - Frontiers in Neuroscience
JF - Frontiers in Neuroscience
SN - 1662-4548
M1 - 982829
ER -
ID: 38050430