TY - JOUR

T1 - Multivariate analysis identifies eight novel loci associated with meat productivity traits in sheep

AU - Zlobin, Alexander S.

AU - Nikulin, Pavel S.

AU - Volkova, Natalia A.

AU - Zinovieva, Natalia A.

AU - Iolchiev, Baylar S.

AU - Bagirov, Vugar A.

AU - Borodin, Pavel M.

AU - Aksenovich, Tatiana I.

AU - Tsepilov, Yakov A.

N1 - Funding Information: Funding: The work of Y.A.T., P.M.B., T.I.A., and N.A.V. was supported by Russian Science Foun‐ dation #18‐16‐00079. The work of A.S.Z. was supported by the Kurchatov Genomics Center of IC&G (075‐15‐2019‐1662). The work of N.A.Z., V.A.B., and B.S.I. was supported by the Ministry of Science and Higher Education of the Russian Federation (theme No. 0445‐2021‐0005). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - Despite their economic value, sheep remain relatively poorly studied animals in terms of the number of known loci and genes associated with commercially important traits. This gap in our knowledge can be filled in by performing new genome‐wide association studies (GWAS) or by re-analyzing previously documented data using novel powerful statistical methods. This study is focused on the search for new loci associated with meat productivity and carcass traits in sheep. With a multivariate approach applied to publicly available GWAS results, we identified eight novel loci associated with the meat productivity and carcass traits in sheep. Using an in silico follow‐up ap-proach, we prioritized 13 genes in these loci. One of eight novel loci near the FAM3C and WNT16 genes has been replicated in an independent sample of Russian sheep populations (N = 108). The novel loci were added to our regularly updated database increasing the number of known loci to more than 140.

AB - Despite their economic value, sheep remain relatively poorly studied animals in terms of the number of known loci and genes associated with commercially important traits. This gap in our knowledge can be filled in by performing new genome‐wide association studies (GWAS) or by re-analyzing previously documented data using novel powerful statistical methods. This study is focused on the search for new loci associated with meat productivity and carcass traits in sheep. With a multivariate approach applied to publicly available GWAS results, we identified eight novel loci associated with the meat productivity and carcass traits in sheep. Using an in silico follow‐up ap-proach, we prioritized 13 genes in these loci. One of eight novel loci near the FAM3C and WNT16 genes has been replicated in an independent sample of Russian sheep populations (N = 108). The novel loci were added to our regularly updated database increasing the number of known loci to more than 140.

KW - GWAS

KW - Meat productivity

KW - Multivariate analysis

KW - Quantitative genetics

KW - Sheep

UR - http://www.scopus.com/inward/record.url?scp=85102822709&partnerID=8YFLogxK

U2 - 10.3390/genes12030367

DO - 10.3390/genes12030367

M3 - Article

C2 - 33806625

AN - SCOPUS:85102822709

VL - 12

SP - 1

EP - 11

JO - Genes

JF - Genes

SN - 2073-4425

IS - 3

M1 - 367

ER -