Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae. / Derežanin, Lorena; Blažytė, Asta; Dobrynin, Pavel и др.
в: Molecular Ecology, Том 31, № 10, 05.2022, стр. 2898-2919.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae
AU - Derežanin, Lorena
AU - Blažytė, Asta
AU - Dobrynin, Pavel
AU - Duchêne, David A.
AU - Grau, José Horacio
AU - Jeon, Sungwon
AU - Kliver, Sergei
AU - Koepfli, Klaus Peter
AU - Meneghini, Dorina
AU - Preick, Michaela
AU - Tomarovsky, Andrey
AU - Totikov, Azamat
AU - Fickel, Jörns
AU - Förster, Daniel W.
N1 - Publisher Copyright: © 2022 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.
PY - 2022/5
Y1 - 2022/5
N2 - Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecological niches. They differ in feeding ecologies, reproductive strategies and morphological adaptations. To identify candidate loci associated with adaptations to their respective environments, we generated a de novo assembly of the tayra (Eira barbara), the earliest diverging species in the subfamily, and compared this with the genomes available for the wolverine (Gulo gulo) and the sable (Martes zibellina). Our comparative genomic analyses included searching for signs of positive selection, examining changes in gene family sizes and searching for species-specific structural variants. Among candidate loci associated with phenotypic traits, we observed many related to diet, body condition and reproduction. For example, for the tayra, which has an atypical gulonine reproductive strategy of aseasonal breeding, we observed species-specific changes in many pregnancy-related genes. For the wolverine, a circumpolar hypercarnivore that must cope with seasonal food scarcity, we observed many changes in genes associated with diet and body condition. All types of genomic variation examined (single nucleotide polymorphisms, gene family expansions, structural variants) contributed substantially to the identification of candidate loci. This argues strongly for consideration of variation other than single nucleotide polymorphisms in comparative genomics studies aiming to identify loci of adaptive significance.
AB - Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecological niches. They differ in feeding ecologies, reproductive strategies and morphological adaptations. To identify candidate loci associated with adaptations to their respective environments, we generated a de novo assembly of the tayra (Eira barbara), the earliest diverging species in the subfamily, and compared this with the genomes available for the wolverine (Gulo gulo) and the sable (Martes zibellina). Our comparative genomic analyses included searching for signs of positive selection, examining changes in gene family sizes and searching for species-specific structural variants. Among candidate loci associated with phenotypic traits, we observed many related to diet, body condition and reproduction. For example, for the tayra, which has an atypical gulonine reproductive strategy of aseasonal breeding, we observed species-specific changes in many pregnancy-related genes. For the wolverine, a circumpolar hypercarnivore that must cope with seasonal food scarcity, we observed many changes in genes associated with diet and body condition. All types of genomic variation examined (single nucleotide polymorphisms, gene family expansions, structural variants) contributed substantially to the identification of candidate loci. This argues strongly for consideration of variation other than single nucleotide polymorphisms in comparative genomics studies aiming to identify loci of adaptive significance.
KW - adaptation
KW - gene family evolution
KW - genomics
KW - mustelids
KW - positive selection
KW - structural variation
KW - Adaptation, Physiological/genetics
KW - Phenotype
KW - Animals
KW - Genomics
KW - Mustelidae/genetics
KW - Genome
UR - http://www.scopus.com/inward/record.url?scp=85127462359&partnerID=8YFLogxK
U2 - 10.1111/mec.16443
DO - 10.1111/mec.16443
M3 - Article
C2 - 35334142
AN - SCOPUS:85127462359
VL - 31
SP - 2898
EP - 2919
JO - Molecular Ecology
JF - Molecular Ecology
SN - 0962-1083
IS - 10
ER -
ID: 35841019