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Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma. / Saik, O. V.; Konovalova, N. A.; Demenkov, P. S. и др.

в: Russian Journal of Genetics: Applied Research, Том 7, № 5, 01.07.2017, стр. 558-564.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Saik, OV, Konovalova, NA, Demenkov, PS, Ivanisenko, NV, Ivanisenko, TV, Ivanoshchuk, DE, Konovalova, OS, Podkolodnaya, OA, Lavrik, IN, Kolchanov, NA & Ivanisenko, VA 2017, 'Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma', Russian Journal of Genetics: Applied Research, Том. 7, № 5, стр. 558-564. https://doi.org/10.1134/S2079059717050173

APA

Saik, O. V., Konovalova, N. A., Demenkov, P. S., Ivanisenko, N. V., Ivanisenko, T. V., Ivanoshchuk, D. E., Konovalova, O. S., Podkolodnaya, O. A., Lavrik, I. N., Kolchanov, N. A., & Ivanisenko, V. A. (2017). Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma. Russian Journal of Genetics: Applied Research, 7(5), 558-564. https://doi.org/10.1134/S2079059717050173

Vancouver

Saik OV, Konovalova NA, Demenkov PS, Ivanisenko NV, Ivanisenko TV, Ivanoshchuk DE и др. Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma. Russian Journal of Genetics: Applied Research. 2017 июль 1;7(5):558-564. doi: 10.1134/S2079059717050173

Author

Saik, O. V. ; Konovalova, N. A. ; Demenkov, P. S. и др. / Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma. в: Russian Journal of Genetics: Applied Research. 2017 ; Том 7, № 5. стр. 558-564.

BibTeX

@article{8406981a5c2241bd9867be0a1a29d71d,
title = "Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma",
abstract = "Glaucoma is a chronic progressive disease. It involves more than 60 million people worldwide. Primary open-angle glaucoma (POAG) is one of its commonest forms. About 2.71 million people in the United States suffered from POAG in 2011. Currently, POAG is a major cause of irreversible vision loss. The risk of blindness in patients with treated open-angle glaucoma is 27%. It is known that the death of optic nerve cells can be triggered by mechanical stress caused by ocular hypertension, which induces neuronal apoptosis and occurs in patients with POAG. Many scientific publications are dedicated to proteins and genes involved in the development of POAG, including neuronal apoptosis and the cell response to mechanical stress (CRMS). However, the molecular mechanisms underlying the pathophysiology of POAG are still poorly understood. The reconstruction of associative networks describing the functional interactions between these genes/proteins, including biochemical reactions, regulatory interactions, and transport, requires automated knowledge extraction from scientific publications. This work aims to analyze the associative networks describing molecular interactions between proteins and genes involved in CRMS, neuronal apoptosis, and the development of POAG. It has been shown that genes associated with POAG are statistically significantly overrepresented among the genes involved in the interactions between CRMS and neuronal apoptosis in comparison to what is expected on a random basis. This finding may explain how POAG causes the death of the retinal ganglion cell.",
keywords = "ANDSystem, apoptosis, associative gene networks, cell response to mechanical stress, neuronal apoptosis, POAG, primary open-angle glaucoma",
author = "Saik, {O. V.} and Konovalova, {N. A.} and Demenkov, {P. S.} and Ivanisenko, {N. V.} and Ivanisenko, {T. V.} and Ivanoshchuk, {D. E.} and Konovalova, {O. S.} and Podkolodnaya, {O. A.} and Lavrik, {I. N.} and Kolchanov, {N. A.} and Ivanisenko, {V. A.}",
note = "Publisher Copyright: {\textcopyright} 2017, Pleiades Publishing, Ltd.",
year = "2017",
month = jul,
day = "1",
doi = "10.1134/S2079059717050173",
language = "English",
volume = "7",
pages = "558--564",
journal = "Russian Journal of Genetics: Applied Research",
issn = "2079-0597",
publisher = "Maik Nauka Publishing / Springer SBM",
number = "5",

}

RIS

TY - JOUR

T1 - Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma

AU - Saik, O. V.

AU - Konovalova, N. A.

AU - Demenkov, P. S.

AU - Ivanisenko, N. V.

AU - Ivanisenko, T. V.

AU - Ivanoshchuk, D. E.

AU - Konovalova, O. S.

AU - Podkolodnaya, O. A.

AU - Lavrik, I. N.

AU - Kolchanov, N. A.

AU - Ivanisenko, V. A.

N1 - Publisher Copyright: © 2017, Pleiades Publishing, Ltd.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Glaucoma is a chronic progressive disease. It involves more than 60 million people worldwide. Primary open-angle glaucoma (POAG) is one of its commonest forms. About 2.71 million people in the United States suffered from POAG in 2011. Currently, POAG is a major cause of irreversible vision loss. The risk of blindness in patients with treated open-angle glaucoma is 27%. It is known that the death of optic nerve cells can be triggered by mechanical stress caused by ocular hypertension, which induces neuronal apoptosis and occurs in patients with POAG. Many scientific publications are dedicated to proteins and genes involved in the development of POAG, including neuronal apoptosis and the cell response to mechanical stress (CRMS). However, the molecular mechanisms underlying the pathophysiology of POAG are still poorly understood. The reconstruction of associative networks describing the functional interactions between these genes/proteins, including biochemical reactions, regulatory interactions, and transport, requires automated knowledge extraction from scientific publications. This work aims to analyze the associative networks describing molecular interactions between proteins and genes involved in CRMS, neuronal apoptosis, and the development of POAG. It has been shown that genes associated with POAG are statistically significantly overrepresented among the genes involved in the interactions between CRMS and neuronal apoptosis in comparison to what is expected on a random basis. This finding may explain how POAG causes the death of the retinal ganglion cell.

AB - Glaucoma is a chronic progressive disease. It involves more than 60 million people worldwide. Primary open-angle glaucoma (POAG) is one of its commonest forms. About 2.71 million people in the United States suffered from POAG in 2011. Currently, POAG is a major cause of irreversible vision loss. The risk of blindness in patients with treated open-angle glaucoma is 27%. It is known that the death of optic nerve cells can be triggered by mechanical stress caused by ocular hypertension, which induces neuronal apoptosis and occurs in patients with POAG. Many scientific publications are dedicated to proteins and genes involved in the development of POAG, including neuronal apoptosis and the cell response to mechanical stress (CRMS). However, the molecular mechanisms underlying the pathophysiology of POAG are still poorly understood. The reconstruction of associative networks describing the functional interactions between these genes/proteins, including biochemical reactions, regulatory interactions, and transport, requires automated knowledge extraction from scientific publications. This work aims to analyze the associative networks describing molecular interactions between proteins and genes involved in CRMS, neuronal apoptosis, and the development of POAG. It has been shown that genes associated with POAG are statistically significantly overrepresented among the genes involved in the interactions between CRMS and neuronal apoptosis in comparison to what is expected on a random basis. This finding may explain how POAG causes the death of the retinal ganglion cell.

KW - ANDSystem

KW - apoptosis

KW - associative gene networks

KW - cell response to mechanical stress

KW - neuronal apoptosis

KW - POAG

KW - primary open-angle glaucoma

UR - http://www.scopus.com/inward/record.url?scp=85028019271&partnerID=8YFLogxK

U2 - 10.1134/S2079059717050173

DO - 10.1134/S2079059717050173

M3 - Article

AN - SCOPUS:85028019271

VL - 7

SP - 558

EP - 564

JO - Russian Journal of Genetics: Applied Research

JF - Russian Journal of Genetics: Applied Research

SN - 2079-0597

IS - 5

ER -

ID: 8966245