TY - JOUR

T1 - Molecular Abnormalities in BTBR Mice and Their Relevance to Schizophrenia and Autism Spectrum Disorders: An Overview of Transcriptomic and Proteomic Studies

AU - Kisaretova, Polina

AU - Tsybko, Anton

AU - Bondar, Natalia

AU - Reshetnikov, Vasiliy

N1 - Funding: The study was supported by a publicly funded project (FWNR-2022-0002, Russia).

PY - 2023/1/20

Y1 - 2023/1/20

N2 - Animal models of psychopathologies are of exceptional interest for neurobiologists because these models allow us to clarify molecular mechanisms underlying the pathologies. One such model is the inbred BTBR strain of mice, which is characterized by behavioral, neuroanatomical, and physiological hallmarks of schizophrenia (SCZ) and autism spectrum disorders (ASDs). Despite the active use of BTBR mice as a model object, the understanding of the molecular features of this strain that cause the observed behavioral phenotype remains insufficient. Here, we analyzed recently published data from independent transcriptomic and proteomic studies on hippocampal and corticostriatal samples from BTBR mice to search for the most consistent aberrations in gene or protein expression. Next, we compared reproducible molecular signatures of BTBR mice with data on postmortem samples from ASD and SCZ patients. Taken together, these data helped us to elucidate brain-region-specific molecular abnormalities in BTBR mice as well as their relevance to the anomalies seen in ASDs or SCZ in humans.

AB - Animal models of psychopathologies are of exceptional interest for neurobiologists because these models allow us to clarify molecular mechanisms underlying the pathologies. One such model is the inbred BTBR strain of mice, which is characterized by behavioral, neuroanatomical, and physiological hallmarks of schizophrenia (SCZ) and autism spectrum disorders (ASDs). Despite the active use of BTBR mice as a model object, the understanding of the molecular features of this strain that cause the observed behavioral phenotype remains insufficient. Here, we analyzed recently published data from independent transcriptomic and proteomic studies on hippocampal and corticostriatal samples from BTBR mice to search for the most consistent aberrations in gene or protein expression. Next, we compared reproducible molecular signatures of BTBR mice with data on postmortem samples from ASD and SCZ patients. Taken together, these data helped us to elucidate brain-region-specific molecular abnormalities in BTBR mice as well as their relevance to the anomalies seen in ASDs or SCZ in humans.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85146535010&origin=inward&txGid=1d5f9e027e01a2ca70b14dd8fc174434

UR - https://www.mendeley.com/catalogue/7eea9849-7ac1-395a-af3a-0843759cd57d/

U2 - 10.3390/biomedicines11020289

DO - 10.3390/biomedicines11020289

M3 - Article

C2 - 36830826

VL - 11

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 2

M1 - 289

ER -