TY - JOUR

T1 - Modulators of Hematopoiesis Disorders (a Review)

AU - Salakhutdinov, N. F.

AU - Laev, S. S.

AU - Sergeevichev, D. S.

PY - 2020

Y1 - 2020

N2 - Disorders of hematopoiesis caused by the action of various factors (hemotoxic substances, drugs, cytotoxic drugs, radiation) lead to a deviation from the norm and the development of the diseases varying in complexity. The restoration of hematopoiesis under extreme conditions is vital, and the search for the drugs stimulating hematopoiesis is an extremely urgent task. The most interesting agents are low molecular weight compounds that can stimulate hematopoiesis in case of its disorders. The presented literature review discusses various factors leading to hematopoietic disorders, and drugs that have shown sufficient effectiveness in eliminating these disorders, in particular with cytostatic therapy and the treatment of hemolytic pathologies. The review can be useful in the search for agents that stimulate hematopoiesis, and is addressed not only to medical and chemical professionals, but also to a wide range of readers.

AB - Disorders of hematopoiesis caused by the action of various factors (hemotoxic substances, drugs, cytotoxic drugs, radiation) lead to a deviation from the norm and the development of the diseases varying in complexity. The restoration of hematopoiesis under extreme conditions is vital, and the search for the drugs stimulating hematopoiesis is an extremely urgent task. The most interesting agents are low molecular weight compounds that can stimulate hematopoiesis in case of its disorders. The presented literature review discusses various factors leading to hematopoietic disorders, and drugs that have shown sufficient effectiveness in eliminating these disorders, in particular with cytostatic therapy and the treatment of hemolytic pathologies. The review can be useful in the search for agents that stimulate hematopoiesis, and is addressed not only to medical and chemical professionals, but also to a wide range of readers.

KW - hematopoiesis

KW - bone marrow

KW - cytostatic drug

KW - hemostimulating activity

KW - anemia

KW - leukemia

KW - ACUTE PROMYELOCYTIC LEUKEMIA

KW - TRANS-RETINOIC ACID

KW - BONE-MARROW

KW - KINASE INHIBITOR

KW - RADIATION-INJURY

KW - PROGENITOR CELLS

KW - IN-VITRO

KW - STEM

KW - CYCLOPHOSPHAMIDE

KW - MELATONIN

U2 - 10.15372/CSD2020239

DO - 10.15372/CSD2020239

M3 - Review article

VL - 28

SP - 332

EP - 353

JO - Chemistry for Sustainable Development

JF - Chemistry for Sustainable Development

SN - 1817-1818

IS - 4

ER -