TY - JOUR

T1 - Mixed-ligand manganese(II) complexes with 5-phenyltetrazole and polypyridine derivatives: Synthesis, crystal structures and biological activity

AU - Ermakova, Ekaterina A.

AU - Eremina, Julia A.

AU - Smirnova, Ksenia S.

AU - Klyushova, Lyubov S.

AU - Kal'nyi, Danila B.

AU - Sukhikh, Taisiya S.

AU - Zubenko, A. A.

AU - Fetisov, L. N.

AU - Kononenko, K. N.

AU - Lider, Elizaveta V.

N1 - Funding Information: The authors thank Anna P. Zubareva and Natalia N. Komardina for the elemental analysis, Anastasia O. Matveeva for the X-ray phase analysis data, Alexander S. Sukhikh and Dmitriy A. Piryazev for providing the data collected in XRD Facility of NIIC SB RAS. The work was performed using the equipment of the Center for Collective Use “Proteomic Analysis”, supported by funding from the Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2021-691). Funding Information: The reported study was funded by RFBR according to the research project № 20-33-90092. This work was supported by the Russian Science Foundation (project №20-73-10207). Funding Information: The reported study was funded by RFBR according to the research project ? 20-33-90092. This work was supported by the Russian Science Foundation (project ?20-73-10207). The research was supported by the Ministry of Science and Higher Education of the Russian Federation, ? 121031700321-3 (Nikolaev Institute of Inorganic Chemistry SB RAS). The authors thank Anna P. Zubareva and Natalia N. Komardina for the elemental analysis, Anastasia O. Matveeva for the X-ray phase analysis data, Alexander S. Sukhikh and Dmitriy A. Piryazev for providing the data collected in XRD Facility of NIIC SB RAS. The work was performed using the equipment of the Center for Collective Use ?Proteomic Analysis?, supported by funding from the Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2021-691). Funding Information: The research was supported by the Ministry of Science and Higher Education of the Russian Federation, № 121031700321-3 (Nikolaev Institute of Inorganic Chemistry SB RAS). Publisher Copyright: © 2021 The Author(s)

PY - 2021/1

Y1 - 2021/1

N2 - Mixed-ligand manganese(II) complexes [Mn3(bipy)2L4(OAc)2] (1), [Mn2(dmbipy)2L2(OAc)2] (2) and [Mn(dmphen)2L2] (3), where L – 5-phenyltetrazolate anion, bipy – 2,2′-bipyridine, dmbipy – 2,2′-bi-4-picoline, dmphen – 4,7-dimethyl-1,10-phenanthroline, have been synthesized and characterized by elemental analysis, IR spectroscopy, cyclic voltammetry and powder X-ray diffraction. Single‐crystal X‐ray diffraction analysis was carried out to determine crystal structures of complexes. The UV-vis spectroscopy has been applied to show the stability of the compounds in solution. The effect of the compounds on viability of HepG2 and Hep-2 cell lines has been investigated. Complex [Mn(dmphen)2L2] was found to be the most cytotoxic with IC50 values of 5.7 ± 0.6 µM (HepG2 cells) and 8.1 ± 1.2 µM (Hep-2 cells). The antimicrobial activity of complexes and ligands has been investigated against E. coli, S. aureus, P. italicum and C. steinii. All complexes have shown protistocidal activity against C. steinii. Complexes have been found to exhibit antioxidant activity measured spectrophotometrically using ABTS•+ radical.

AB - Mixed-ligand manganese(II) complexes [Mn3(bipy)2L4(OAc)2] (1), [Mn2(dmbipy)2L2(OAc)2] (2) and [Mn(dmphen)2L2] (3), where L – 5-phenyltetrazolate anion, bipy – 2,2′-bipyridine, dmbipy – 2,2′-bi-4-picoline, dmphen – 4,7-dimethyl-1,10-phenanthroline, have been synthesized and characterized by elemental analysis, IR spectroscopy, cyclic voltammetry and powder X-ray diffraction. Single‐crystal X‐ray diffraction analysis was carried out to determine crystal structures of complexes. The UV-vis spectroscopy has been applied to show the stability of the compounds in solution. The effect of the compounds on viability of HepG2 and Hep-2 cell lines has been investigated. Complex [Mn(dmphen)2L2] was found to be the most cytotoxic with IC50 values of 5.7 ± 0.6 µM (HepG2 cells) and 8.1 ± 1.2 µM (Hep-2 cells). The antimicrobial activity of complexes and ligands has been investigated against E. coli, S. aureus, P. italicum and C. steinii. All complexes have shown protistocidal activity against C. steinii. Complexes have been found to exhibit antioxidant activity measured spectrophotometrically using ABTS•+ radical.

KW - 5-phenyltetrazole

KW - Antimicrobial and antioxidant activity

KW - Cytotoxicity

KW - Manganese(II) complexes

KW - Polypyridine

UR - http://www.scopus.com/inward/record.url?scp=85119621193&partnerID=8YFLogxK

U2 - 10.1016/j.rechem.2021.100239

DO - 10.1016/j.rechem.2021.100239

M3 - Article

AN - SCOPUS:85119621193

VL - 3

JO - Results in Chemistry

JF - Results in Chemistry

SN - 2211-7156

M1 - 100239

ER -