Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
Methods for Assessment of Nucleotide Excision Repair Efficiency. / Popov, Aleksei A.; Petruseva, Irina O.; Naumenko, Natalya V. и др.
в: Biochemistry (Moscow), Том 88, № 11, 11.2023, стр. 1844-1856.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
}
TY - JOUR
T1 - Methods for Assessment of Nucleotide Excision Repair Efficiency
AU - Popov, Aleksei A.
AU - Petruseva, Irina O.
AU - Naumenko, Natalya V.
AU - Lavrik, Olga I.
N1 - This work was supported by the Russian Science Foundation (project no. 19-74-10056-P) and by the State Assignment for the Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences (no. 121031300041-4, “Nucleotide Excision Repair System” section). Публикация для корректировки.
PY - 2023/11
Y1 - 2023/11
N2 - Nucleotide excision repair (NER) is responsible for removing a wide variety of bulky adducts from DNA, thus contributing to the maintenance of genome stability. The efficiency with which proteins of the NER system recognize and remove bulky adducts depends on many factors and is of great clinical and diagnostic significance. The review examines current concepts of the NER system molecular basis in eukaryotic cells and analyzes methods for the assessment of the NER-mediated DNA repair efficiency both in vitro and ex vivo.
AB - Nucleotide excision repair (NER) is responsible for removing a wide variety of bulky adducts from DNA, thus contributing to the maintenance of genome stability. The efficiency with which proteins of the NER system recognize and remove bulky adducts depends on many factors and is of great clinical and diagnostic significance. The review examines current concepts of the NER system molecular basis in eukaryotic cells and analyzes methods for the assessment of the NER-mediated DNA repair efficiency both in vitro and ex vivo.
KW - DNA damage
KW - methods for determining NER activity
KW - nucleotide excision repair
KW - DNA/metabolism
KW - DNA Repair
KW - DNA Damage
KW - Excision Repair
KW - Nucleotides
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85178227709&origin=inward&txGid=1b50c7e3c9a211a0b19e36ad9657a813
UR - https://www.mendeley.com/catalogue/e73baac7-376a-399c-8408-83cd2f55e6ab/
U2 - 10.1134/S0006297923110147
DO - 10.1134/S0006297923110147
M3 - Review article
C2 - 38105203
VL - 88
SP - 1844
EP - 1856
JO - Biochemistry (Moscow)
JF - Biochemistry (Moscow)
SN - 0006-2979
IS - 11
ER -
ID: 59546728