TY - JOUR

T1 - Maturation of Neonatal Reflexes and Behavioral Features in 5xFAD Mice, a Model of Alzheimer’s Disease

AU - Rozhkova, I. N.

AU - Brusentsev, E. Yu.

AU - Rakhmanova, T. A.

AU - Kozeneva, V. S.

AU - Khotskin, N. V.

AU - Amstislavsky, S. Ya.

N1 - This work was supported by the Russian Science Foundation (RSF grant no. 25-24-00153). No other grants to conduct or supervise this particular research were obtained. Maturation of Neonatal Reflexes and Behavioral Features in 5xFAD Mice, a Model of Alzheimer's Disease / I. N. Rozhkova, E. Yu. Brusentsev, T. A. Rakhmanova [et al.] // Journal of Evolutionary Biochemistry and Physiology. – 2025. – Vol. 61, No. 4. – P. 1274-1289. – DOI 10.1134/S0022093025040271.

PY - 2025/9/5

Y1 - 2025/9/5

N2 - Alzheimer’s disease (AD) is a progressive age-related neurodegenerative pathology leading to dementia. Genetic mouse models of AD have been created to investigate the mechanisms underlying this pathology and to search for possible ways or its correction. Transgenic 5xFAD mice carrying two human transgenes, App and Psen1, and five mutations, are a popular model to study AD. The aim of this work was to assess the maturation of neonatal reflexes and body weight gain during early postnatal ontogenesis of 5xFAD mice, as well as behavioral features of these animals at the age of three months. Wild-type (WT) mice of the same sex and age from the same litters were used as controls. The obtained results show that 5xFAD mice do not differ from their WT siblings in body weight gain and the formation of neonatal reflexes during the suckling period. At the age of three months, 5xFAD mice revealed sex differences in their behavior: males exhibited lower overall locomotor activity than females and showed signs of incipient depression-like behavior. Male 5xFAD mice had reduced anxiety levels, while females showed increased exploratory activity compared to WT siblings of the same sex. Thus, the behavioral features of 5xFAD mice were characterized at the age of three months. For the first time, the maturation of neonatal reflexes during the suckling period has been studied in this transgenic model of AD.

AB - Alzheimer’s disease (AD) is a progressive age-related neurodegenerative pathology leading to dementia. Genetic mouse models of AD have been created to investigate the mechanisms underlying this pathology and to search for possible ways or its correction. Transgenic 5xFAD mice carrying two human transgenes, App and Psen1, and five mutations, are a popular model to study AD. The aim of this work was to assess the maturation of neonatal reflexes and body weight gain during early postnatal ontogenesis of 5xFAD mice, as well as behavioral features of these animals at the age of three months. Wild-type (WT) mice of the same sex and age from the same litters were used as controls. The obtained results show that 5xFAD mice do not differ from their WT siblings in body weight gain and the formation of neonatal reflexes during the suckling period. At the age of three months, 5xFAD mice revealed sex differences in their behavior: males exhibited lower overall locomotor activity than females and showed signs of incipient depression-like behavior. Male 5xFAD mice had reduced anxiety levels, while females showed increased exploratory activity compared to WT siblings of the same sex. Thus, the behavioral features of 5xFAD mice were characterized at the age of three months. For the first time, the maturation of neonatal reflexes during the suckling period has been studied in this transgenic model of AD.

KW - ALZHEIMER’S DISEASE

KW - 5XFAD MICE

KW - NEONATAL REFLEXES

KW - behaviour

KW - LOCOMOTOR ACTIVITY

KW - Anxiety

KW - Memory

UR - https://www.mendeley.com/catalogue/0738beb4-3667-3649-a12d-a5ef0532862b/

UR - https://elibrary.ru/item.asp?id=82850464

U2 - 10.1134/s0022093025040271

DO - 10.1134/s0022093025040271

M3 - Article

VL - 61

SP - 1274

EP - 1289

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 4

ER -