TY - JOUR

T1 - Mathematical Modeling of Embolization of Arteriovenous Malformations with Overflows on the Basis of the Two-Phase Filtering

AU - Gologush, T. S.

AU - Ostapenko, V. V.

AU - Cherevko, A. A.

N1 - Funding Information: Sections 5–7 of this work were supported by the Government of the Russian Federation, project no. 14.W03.31.0002. Publisher Copyright: © 2021, Pleiades Publishing, Ltd.

PY - 2021/9

Y1 - 2021/9

N2 - Arteriovenous malformation (AVM) is a congenital pathology of the development of brain vessels in which the arterial and venous blood beds are directly connected by tangled degenerate vessels. This dangerous disease affects the brain functioning and increasing the risk of intracranial hemorrhage. A method of treating the AVM is embolization, which is the surgery of endovascular filling of AVM vessels by a special embolic agent to block blood flow through them. This method is widely used; however, it sometimes is accompanied by intraoperative rupture of AVM vessels. A combined model of the embolization process is proposed that, in addition to the flow of blood and embolic agent in the AVM, takes into account the overflow of blood into surrounding healthy vessels. For modeling the joint flow of blood and embolic composition within the AVM, a one-dimensional model of two-phase filtering is used. This model is built on the basis of clinical data of real patients obtained during neurosurgeries in the Meshalkin National Medical Research Center. Mathematically, this leads to a special initial boundary value problem for an integro-differential equation with a nonconvex flow. For numerical computations, a monotone modification of the CABARET scheme is constructed that highly accurately localizes the strong and weak discontinuities in the solution to the problem. The main purpose of this paper is to find the optimal scenario of the AVM embolization with respect to safety and efficiency. The objective functional and the constraints occurring in the resulting optimal control problem are chosen according to medical grounds. In the future, it is planned to use the optimal solutions obtained in this paper to improve the surgery technique and increase the safety of neurosurgical operations.

AB - Arteriovenous malformation (AVM) is a congenital pathology of the development of brain vessels in which the arterial and venous blood beds are directly connected by tangled degenerate vessels. This dangerous disease affects the brain functioning and increasing the risk of intracranial hemorrhage. A method of treating the AVM is embolization, which is the surgery of endovascular filling of AVM vessels by a special embolic agent to block blood flow through them. This method is widely used; however, it sometimes is accompanied by intraoperative rupture of AVM vessels. A combined model of the embolization process is proposed that, in addition to the flow of blood and embolic agent in the AVM, takes into account the overflow of blood into surrounding healthy vessels. For modeling the joint flow of blood and embolic composition within the AVM, a one-dimensional model of two-phase filtering is used. This model is built on the basis of clinical data of real patients obtained during neurosurgeries in the Meshalkin National Medical Research Center. Mathematically, this leads to a special initial boundary value problem for an integro-differential equation with a nonconvex flow. For numerical computations, a monotone modification of the CABARET scheme is constructed that highly accurately localizes the strong and weak discontinuities in the solution to the problem. The main purpose of this paper is to find the optimal scenario of the AVM embolization with respect to safety and efficiency. The objective functional and the constraints occurring in the resulting optimal control problem are chosen according to medical grounds. In the future, it is planned to use the optimal solutions obtained in this paper to improve the surgery technique and increase the safety of neurosurgical operations.

KW - arteriovenous malformation

KW - CABARET scheme

KW - embolization

KW - optimal control

KW - two-phase filtering

UR - http://www.scopus.com/inward/record.url?scp=85117283729&partnerID=8YFLogxK

U2 - 10.1134/S0965542521090104

DO - 10.1134/S0965542521090104

M3 - Article

AN - SCOPUS:85117283729

VL - 61

SP - 1546

EP - 1558

JO - Computational Mathematics and Mathematical Physics

JF - Computational Mathematics and Mathematical Physics

SN - 0965-5425

IS - 9

M1 - 13

ER -