TY - JOUR

T1 - Manganese oxide nanoparticles: the influence of manganese oxidation state on selective lysis of tumor cells

AU - Razumov, Ivan

AU - Troitskii, Sergei

AU - Solovieva, Olga

AU - Suprun, Evgenii

N1 - The studies were supported by the budget project (No. FWNR-2022-0023) and implemented using the facilities of the Center for Genetic Resources of Laboratory Animals at ICG SB RAS, supported by the Ministry of Education and Science of Russia (RFMEFI62119X0023).

PY - 2023/7

Y1 - 2023/7

N2 - Further studies on the mechanism of intracellular induction of active oxygen species and selective oncolysis with metal oxide nanoparticles (NPs), as well as the discussion of alternative mechanisms of the NPs impact on tumor cells, are needed to introduce nanotechnologies into antitumor therapy. The paper concerns the inhibition of oxidation processes in tumor cells under the action of manganese oxide-based NPs (size 10–60 nm) as the mechanism of a tumor cell death. When manganese (II) hydroxide-based NPs enter the cells, they are oxidized with oxygen to Mn4+ compounds; the oxidation processes being blocked in the tumor cells. Hence, the MnO NPs cytotoxicity can be due to the possible direct reduction of O2 in the presence of manganese compounds in the cells.

AB - Further studies on the mechanism of intracellular induction of active oxygen species and selective oncolysis with metal oxide nanoparticles (NPs), as well as the discussion of alternative mechanisms of the NPs impact on tumor cells, are needed to introduce nanotechnologies into antitumor therapy. The paper concerns the inhibition of oxidation processes in tumor cells under the action of manganese oxide-based NPs (size 10–60 nm) as the mechanism of a tumor cell death. When manganese (II) hydroxide-based NPs enter the cells, they are oxidized with oxygen to Mn4+ compounds; the oxidation processes being blocked in the tumor cells. Hence, the MnO NPs cytotoxicity can be due to the possible direct reduction of O2 in the presence of manganese compounds in the cells.

KW - Human tumor cells

KW - Manganese oxides

KW - Nanoparticles

KW - Redox mechanism

KW - Selective oncolysis

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85163857059&origin=inward&txGid=7bcd2301ecafa423a352643b8a87baf3

UR - https://www.mendeley.com/catalogue/1ecaf2f9-7266-35f3-9ff0-e1c95b6dbb90/

U2 - 10.1007/s11051-023-05782-7

DO - 10.1007/s11051-023-05782-7

M3 - Article

VL - 25

JO - Journal of Nanoparticle Research

JF - Journal of Nanoparticle Research

SN - 1388-0764

IS - 7

M1 - 140

ER -