Manganese Oxide Nanoparticles Inhibit the Growth of Subcutaneous U-87MG Glioblastoma Xenografts in Immunodeficient Mouse

Standard

Manganese Oxide Nanoparticles Inhibit the Growth of Subcutaneous U-87MG Glioblastoma Xenografts in Immunodeficient Mouse. / Razumov, I. A.; Troitskii, S. Yu; Solov’eva, O. I. и др.

в: Bulletin of Experimental Biology and Medicine, Том 170, № 1, 11.2020, стр. 148-153.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Razumov, IA, Troitskii, SY, Solov’eva, OI, Boldyrev, ND & Zavjalov, EL 2020, 'Manganese Oxide Nanoparticles Inhibit the Growth of Subcutaneous U-87MG Glioblastoma Xenografts in Immunodeficient Mouse', Bulletin of Experimental Biology and Medicine, Том. 170, № 1, стр. 148-153. https://doi.org/10.1007/s10517-020-05021-2

APA

Razumov, I. A., Troitskii, S. Y., Solov’eva, O. I., Boldyrev, N. D., & Zavjalov, E. L. (2020). Manganese Oxide Nanoparticles Inhibit the Growth of Subcutaneous U-87MG Glioblastoma Xenografts in Immunodeficient Mouse. Bulletin of Experimental Biology and Medicine, 170(1), 148-153. https://doi.org/10.1007/s10517-020-05021-2

Vancouver

Razumov IA, Troitskii SY, Solov’eva OI, Boldyrev ND, Zavjalov EL. Manganese Oxide Nanoparticles Inhibit the Growth of Subcutaneous U-87MG Glioblastoma Xenografts in Immunodeficient Mouse. Bulletin of Experimental Biology and Medicine. 2020 нояб.;170(1):148-153. doi: 10.1007/s10517-020-05021-2

Author

Razumov, I. A. ; Troitskii, S. Yu ; Solov’eva, O. I. и др. / Manganese Oxide Nanoparticles Inhibit the Growth of Subcutaneous U-87MG Glioblastoma Xenografts in Immunodeficient Mouse. в: Bulletin of Experimental Biology and Medicine. 2020 ; Том 170, № 1. стр. 148-153.

BibTeX

@article{8e20019ee1474d288b707b72df1b7175,

title = "Manganese Oxide Nanoparticles Inhibit the Growth of Subcutaneous U-87MG Glioblastoma Xenografts in Immunodeficient Mouse",

abstract = "Our previous study demonstrated that manganese oxide nanoparticles (MnO NP) selectively destroyed U-87MG and U251 human glioblastoma cells in vitro. MnO NP were synthesized and studied by electron microscopy. Their antitumor properties were studied in vivo on the model of immunodeficient SCID mice with subcutaneous xenografts of U-87MG human glioblastoma. The mice were injected subcutaneously with MnO NP in doses of 0.96 and 1.92 mg/kg (calculated for Mn) 3 days a week over 3 weeks. In was shown that MnO NP in these doses significantly suppressed the growth of U-87MG glioblastoma xenografts: on day 21 from the start of the treatment, the tumor growth inhibition index was 61.1 and 99.22%, respectively. These results indicate the necessity of the further studies of MnO NP as a potential oncolytic agent for the therapy of human glioblastomas.",

keywords = "glioblastoma, manganese oxide, nanoparticles, U-87MG, xenotransplantation",

author = "Razumov, {I. A.} and Troitskii, {S. Yu} and Solov{\textquoteright}eva, {O. I.} and Boldyrev, {N. D.} and Zavjalov, {E. L.}",

year = "2020",

month = nov,

doi = "10.1007/s10517-020-05021-2",

language = "English",

volume = "170",

pages = "148--153",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "0007-4888",

publisher = "Springer New York",

number = "1",

}

RIS

TY - JOUR

T1 - Manganese Oxide Nanoparticles Inhibit the Growth of Subcutaneous U-87MG Glioblastoma Xenografts in Immunodeficient Mouse

AU - Razumov, I. A.

AU - Troitskii, S. Yu

AU - Solov’eva, O. I.

AU - Boldyrev, N. D.

AU - Zavjalov, E. L.

PY - 2020/11

Y1 - 2020/11

N2 - Our previous study demonstrated that manganese oxide nanoparticles (MnO NP) selectively destroyed U-87MG and U251 human glioblastoma cells in vitro. MnO NP were synthesized and studied by electron microscopy. Their antitumor properties were studied in vivo on the model of immunodeficient SCID mice with subcutaneous xenografts of U-87MG human glioblastoma. The mice were injected subcutaneously with MnO NP in doses of 0.96 and 1.92 mg/kg (calculated for Mn) 3 days a week over 3 weeks. In was shown that MnO NP in these doses significantly suppressed the growth of U-87MG glioblastoma xenografts: on day 21 from the start of the treatment, the tumor growth inhibition index was 61.1 and 99.22%, respectively. These results indicate the necessity of the further studies of MnO NP as a potential oncolytic agent for the therapy of human glioblastomas.

AB - Our previous study demonstrated that manganese oxide nanoparticles (MnO NP) selectively destroyed U-87MG and U251 human glioblastoma cells in vitro. MnO NP were synthesized and studied by electron microscopy. Their antitumor properties were studied in vivo on the model of immunodeficient SCID mice with subcutaneous xenografts of U-87MG human glioblastoma. The mice were injected subcutaneously with MnO NP in doses of 0.96 and 1.92 mg/kg (calculated for Mn) 3 days a week over 3 weeks. In was shown that MnO NP in these doses significantly suppressed the growth of U-87MG glioblastoma xenografts: on day 21 from the start of the treatment, the tumor growth inhibition index was 61.1 and 99.22%, respectively. These results indicate the necessity of the further studies of MnO NP as a potential oncolytic agent for the therapy of human glioblastomas.

KW - glioblastoma

KW - manganese oxide

KW - nanoparticles

KW - U-87MG

KW - xenotransplantation

UR - http://www.scopus.com/inward/record.url?scp=85096492086&partnerID=8YFLogxK

U2 - 10.1007/s10517-020-05021-2

DO - 10.1007/s10517-020-05021-2

M3 - Article

C2 - 33231805

AN - SCOPUS:85096492086

VL - 170

SP - 148

EP - 153

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -

ID: 26141024