TY - JOUR

T1 - Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride-co-trifluoroethylene) and magnetite particles with varied sizes

AU - Botvin, Vladimir V.

AU - Surmeneva, Maria A.

AU - Mukhortova, Yulia R.

AU - Belyakova, Elizaveta O.

AU - Wagner, Dmitriy V.

AU - Chelobanov, Boris P.

AU - Laktionov, Pavel P.

AU - Sukhinina, Ekaterina V.

AU - Pershina, Alexandra G.

AU - Kholkin, Andrei L.

AU - Surmenev, Roman A.

N1 - Funding Information: FCT/MEC (PIDDAC), Grant/Award Numbers: LA/P/0006/2020, UIDB/50011/2020, UIDP/50011/2020; Ministry of Science and Higher Education, Grant/Award Number: 075‐15‐2021‐588; Tomsk Polytechnic University Development Program Funding information Funding Information: The research was carried out at Tomsk Polytechnic University within the framework of Tomsk Polytechnic University Development Program. The financial support from the Ministry of Science and Higher Education is acknowledged (grant agreement #075‐15‐2021‐588 from 1.06.2021). This work was developed within the scope of project CICECO‐Aveiro Institute of Materials (UIDB/50011/2020, UIDP/50011/2020) & LA/P/0006/2020 financed by national funds through the FCT/MEC (PIDDAC). Publisher Copyright: © 2022 Society of Plastics Engineers.

PY - 2022/5

Y1 - 2022/5

N2 - The development of functional magnetoactive materials fabricated in the form of electrospun scaffolds is of paramount importance for modern medicine and pharmaceuticals. To precisely control the morphology and magnetic properties of the composite magnetoactive scaffolds, the electrospinning conditions, incorporation method of magnetic particles into the polymer solution to avoid agglomeration, and the shape/size of the particles should be thoroughly studied. In this study, hybrid magnetoactive scaffolds based on poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)), doped with either unmodified magnetite (Fe3O4) or magnetite particles modified with oleic acid (Fe3O4/OA), have been fabricated by electrospinning. Modification of magnetite particles by oleic acid results in the formation of nanosized particles in comparison with submicron-sized Fe3O4 particles (37 vs. 329 nm), which reveal a greater affinity to P(VDF-TrFE) due to their hydrophobic surface. Composite scaffolds prepared using 30 wt% polymer solution with 8 wt% Fe3O4 and Fe3O4/OA reveal saturation magnetization values of 9.14 and 5.8 emu/g, respectively. The saturation magnetization of composite scaffolds agrees well with the saturation magnetization of the initial magnetites. Considering the better dispersion of Fe3O4/OA in the polymer solution, a series of composite scaffolds with 4 and 12 wt% concentrations of magnetite have been studied. Cytotoxicity tests demonstrated that all the fabricated composite scaffolds are nontoxic to human cells. Variation of magnetite particles content in the polymer fibers enables to obtain composite scaffolds with tailored saturation magnetization, which can be potentially used as perspective magnetoactive and magnetoelectric materials for biomedical application.

AB - The development of functional magnetoactive materials fabricated in the form of electrospun scaffolds is of paramount importance for modern medicine and pharmaceuticals. To precisely control the morphology and magnetic properties of the composite magnetoactive scaffolds, the electrospinning conditions, incorporation method of magnetic particles into the polymer solution to avoid agglomeration, and the shape/size of the particles should be thoroughly studied. In this study, hybrid magnetoactive scaffolds based on poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)), doped with either unmodified magnetite (Fe3O4) or magnetite particles modified with oleic acid (Fe3O4/OA), have been fabricated by electrospinning. Modification of magnetite particles by oleic acid results in the formation of nanosized particles in comparison with submicron-sized Fe3O4 particles (37 vs. 329 nm), which reveal a greater affinity to P(VDF-TrFE) due to their hydrophobic surface. Composite scaffolds prepared using 30 wt% polymer solution with 8 wt% Fe3O4 and Fe3O4/OA reveal saturation magnetization values of 9.14 and 5.8 emu/g, respectively. The saturation magnetization of composite scaffolds agrees well with the saturation magnetization of the initial magnetites. Considering the better dispersion of Fe3O4/OA in the polymer solution, a series of composite scaffolds with 4 and 12 wt% concentrations of magnetite have been studied. Cytotoxicity tests demonstrated that all the fabricated composite scaffolds are nontoxic to human cells. Variation of magnetite particles content in the polymer fibers enables to obtain composite scaffolds with tailored saturation magnetization, which can be potentially used as perspective magnetoactive and magnetoelectric materials for biomedical application.

KW - composites

KW - electrospinning

KW - fluoropolymers

KW - magnetite

KW - scaffold

UR - http://www.scopus.com/inward/record.url?scp=85125521897&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/4123cd6c-a2bf-393b-81e1-f477f0e815c2/

U2 - 10.1002/pen.25947

DO - 10.1002/pen.25947

M3 - Article

AN - SCOPUS:85125521897

VL - 62

SP - 1593

EP - 1607

JO - Polymer Engineering and Science

JF - Polymer Engineering and Science

SN - 0032-3888

IS - 5

ER -