TY - JOUR

T1 - Magnetic resonance in the evaluation of circulation and mass transfer in human

AU - Tulupov, A. A.

AU - Korostyshevskaya, A. M.

AU - Savelov, A. A.

AU - Stankevich, Y. A.

AU - Bogomyakova, O. B.

AU - Vasil’kiv, L. M.

AU - Petrovskii, E. D.

AU - Zhuravleva, K. V.

AU - Sagdeev, R. Z.

N1 - Funding Information: This study was financially supported by the Russian Science Foundation (Project No. 19-75-20142 in part of the description of possibilities of the mapping method of the macromolecular proton fraction; Project No. 19-75-20093 in part of the evaluation of the magistral blood flow, cerebrospinal fluid circulation, and diffusion-tensor and diffusion-kurtosis MRI during ischemia; and Project No. 19-75-00052 in part of the evaluation of capillary perfusion in the brain) and the Russian Foundation for Basic Research (Project No. 20-15-00385 in part of functional MRI). Funding Information: The authors are grateful to the Ministry of Science and Higher Education of the Russian Federation for access to the MRI equipment. Publisher Copyright: © 2021, Springer Science+Business Media LLC.

PY - 2021/12

Y1 - 2021/12

N2 - The purpose of this study is to highlight the modern possibilities of magnetic resonance as a unique method for assessing and visualizing living systems from the standpoint of chemistry and physics, in particular, from the standpoint of biochemistry and biophysics of metabolism: circulation and mass transfer of protons as a part of water and macromolecules due to flow, diffusion, and perfusion effects in tissues. The main sections of the review are devoted to the use of the mapping method of the macromolecular proton fraction for the determination of the biochemical composition of tissues, evaluation of free diffusion of molecules based on diffusion-tensor and diffusion-kurtosis magnetic resonance tomography (MRI), analysis of the mass transfer of protons in human body fluids due to the flow (circulation) and perfusion effects in the permeable tubular structures (vessels), as well as in complex multicomponent life support systems of the human central nervous system. The effects of oxy- and deoxyhemoglobin conversions during cognitive disorders are specially considered. The results obtained by the listed MRI techniques are used in the construction of models of proton, macromolecular, cellular, and system interactions in living systems.

AB - The purpose of this study is to highlight the modern possibilities of magnetic resonance as a unique method for assessing and visualizing living systems from the standpoint of chemistry and physics, in particular, from the standpoint of biochemistry and biophysics of metabolism: circulation and mass transfer of protons as a part of water and macromolecules due to flow, diffusion, and perfusion effects in tissues. The main sections of the review are devoted to the use of the mapping method of the macromolecular proton fraction for the determination of the biochemical composition of tissues, evaluation of free diffusion of molecules based on diffusion-tensor and diffusion-kurtosis magnetic resonance tomography (MRI), analysis of the mass transfer of protons in human body fluids due to the flow (circulation) and perfusion effects in the permeable tubular structures (vessels), as well as in complex multicomponent life support systems of the human central nervous system. The effects of oxy- and deoxyhemoglobin conversions during cognitive disorders are specially considered. The results obtained by the listed MRI techniques are used in the construction of models of proton, macromolecular, cellular, and system interactions in living systems.

KW - circulation

KW - magnetic resonance imaging

KW - mass transfer in living systems

UR - http://www.scopus.com/inward/record.url?scp=85123587364&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/5699bbf0-cb7b-305c-ab9b-c5fda06c8fb7/

U2 - 10.1007/s11172-021-3344-7

DO - 10.1007/s11172-021-3344-7

M3 - Review article

AN - SCOPUS:85123587364

VL - 70

SP - 2266

EP - 2277

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 12

ER -