TY - JOUR

T1 - Lung cancer cells detection by a photoelectrochemical MoS 2 biosensing chip

AU - Lai, Chun-Liang

AU - Karmakar, Riya

AU - Mukundan, Arvind

AU - Chen, Wei-Chung

AU - Wu, I-Chen

AU - Fedorov, Vladimir E.

AU - Feng, Shih-Wei

AU - Choomjinda, Ubol

AU - Huang, Shu-Fang

AU - Wang, Hsiang-Chen

N1 - Kaohsiung Armed Forces General Hospital (KAFGH-D-111011); Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation-National Chung Cheng University Joint Research Program (DTCRD112-C-09); National Science and Technology Council (NSTC 112-2221-E-194-036, NSTC 112-2222-E-194-002).

PY - 2024/2/10

Y1 - 2024/2/10

N2 - This research aims to explore the potential application of this approach in the production of biosensor chips. The biosensor chip is utilized for the identification and examination of early-stage lung cancer cells. The findings of the optical microscope were corroborated by the field emission scanning electron microscopy, which provided further evidence that the growth of MoS 2 is uniform and that there is minimal disruption in the electrode, hence minimizing the likelihood of an open circuit creation. Furthermore, the bilayer structure of the produced MoS 2 has been validated through the utilization of Raman spectroscopy. A research investigation was undertaken to measure the photoelectric current generated by three various types of clinical samples containing lung cancer cells, specifically the CL1, NCI-H460, and NCI-H520 cell lines. The findings from the empirical analysis indicate that the coefficient of determination (R-Square) for the linear regression model was approximately 98%. Furthermore, the integration of a double-layer MoS 2 film resulted in a significant improvement of 38% in the photocurrent, as observed in the device's performance.

AB - This research aims to explore the potential application of this approach in the production of biosensor chips. The biosensor chip is utilized for the identification and examination of early-stage lung cancer cells. The findings of the optical microscope were corroborated by the field emission scanning electron microscopy, which provided further evidence that the growth of MoS 2 is uniform and that there is minimal disruption in the electrode, hence minimizing the likelihood of an open circuit creation. Furthermore, the bilayer structure of the produced MoS 2 has been validated through the utilization of Raman spectroscopy. A research investigation was undertaken to measure the photoelectric current generated by three various types of clinical samples containing lung cancer cells, specifically the CL1, NCI-H460, and NCI-H520 cell lines. The findings from the empirical analysis indicate that the coefficient of determination (R-Square) for the linear regression model was approximately 98%. Furthermore, the integration of a double-layer MoS 2 film resulted in a significant improvement of 38% in the photocurrent, as observed in the device's performance.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85184517284&origin=inward&txGid=bb22b8957019088eae7bef6d20ec1798

UR - https://www.mendeley.com/catalogue/bdf89eae-8836-3ce7-afc3-73fa2faa9a74/

U2 - 10.1364/boe.511900

DO - 10.1364/boe.511900

M3 - Article

VL - 15

SP - 753

EP - 771

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 2

ER -