TY - JOUR

T1 - Low-frequency Oscillations of Functional Indicators of the Body

AU - Grishin, O. V.

AU - Grishin, V. G.

N1 - This study was carried out as part of a basic project of fundamental research of the Russian Academy of Sciences IV 35.2.6, project no. AAAAA-A21-121011990040-8.

PY - 2024/2

Y1 - 2024/2

N2 - It has been shown in a number of our studies that low-frequency (LF) oscillations in the functional parameters of the oxygen transport system are stable and synchronized with each other. The literature presents a large number of examples of LF oscillations of various functional indicators that are directly or indirectly related to energy metabolism. In parallel, for more than 40 years, artificially induced attenuated and constant spontaneous oscillations in the energization levels of mitochondria in the same LF range have been studied. The aim of this review is to consider a possible relationship between oscillations in the functional parameters of the oxygen transport system and the functional parameters of mitochondria in the very-low-frequency (VLF) range common to them (0.003–0.03 Hz). We believe that a common source for all these oscillations is the periodic dynamics of “energization” in mitochondria united in mitochondrial networks. The process of generating these oscillations proceeds in two phases. In the first phase, the inflow of Ca2+ into the mitochondria exceeds the outflow and enhances the activity of oxidative phosphorylation. In the second phase, the outflow of Ca2+ from the mitochondria prevails over the inflow and is accompanied by the inhibition of oxidative phosphorylation. The oscillations are of a constant spontaneous nature and are based on autocatalytic regulation based on the feedback principle. The inertia of the full cycle processes (first and second phases) lasting 1–3 min may be due to the capacity of the mitochondrial phosphate buffer. The mitochondrial networks of excitable tissues can be the structural basis for synchronizing oscillations at the tissue level. Synchronization at the body level between mitochondrial oscillations and oscillations in indicators related to energy metabolism can be carried out through a system of tunneling nanotubes.

AB - It has been shown in a number of our studies that low-frequency (LF) oscillations in the functional parameters of the oxygen transport system are stable and synchronized with each other. The literature presents a large number of examples of LF oscillations of various functional indicators that are directly or indirectly related to energy metabolism. In parallel, for more than 40 years, artificially induced attenuated and constant spontaneous oscillations in the energization levels of mitochondria in the same LF range have been studied. The aim of this review is to consider a possible relationship between oscillations in the functional parameters of the oxygen transport system and the functional parameters of mitochondria in the very-low-frequency (VLF) range common to them (0.003–0.03 Hz). We believe that a common source for all these oscillations is the periodic dynamics of “energization” in mitochondria united in mitochondrial networks. The process of generating these oscillations proceeds in two phases. In the first phase, the inflow of Ca2+ into the mitochondria exceeds the outflow and enhances the activity of oxidative phosphorylation. In the second phase, the outflow of Ca2+ from the mitochondria prevails over the inflow and is accompanied by the inhibition of oxidative phosphorylation. The oscillations are of a constant spontaneous nature and are based on autocatalytic regulation based on the feedback principle. The inertia of the full cycle processes (first and second phases) lasting 1–3 min may be due to the capacity of the mitochondrial phosphate buffer. The mitochondrial networks of excitable tissues can be the structural basis for synchronizing oscillations at the tissue level. Synchronization at the body level between mitochondrial oscillations and oscillations in indicators related to energy metabolism can be carried out through a system of tunneling nanotubes.

KW - VLF oscillations

KW - calcium ions

KW - cellular respiration

KW - mitochondria

KW - mitochondrial membrane potential

KW - mitochondrial networks

KW - mitochondrial oscillations

KW - oxidative phosphorylation

KW - oxygen transport system

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85197550493&origin=inward&txGid=7a3dc9c59103dad08d937e11e13dd166

UR - https://www.mendeley.com/catalogue/ec195336-8737-374b-aa51-9b0792990666/

U2 - 10.1134/S000635092470012X

DO - 10.1134/S000635092470012X

M3 - Article

VL - 69

SP - 110

EP - 123

JO - Biophysics (Russian Federation)

JF - Biophysics (Russian Federation)

SN - 0006-3509

IS - 1

ER -