Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors

Standard

Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors. / Tsygankova, Alphiya R.; Gruzdev, Dmitry A.; Kanygin, Vladimir V. и др.

в: Mendeleev Communications, Том 31, № 5, 01.09.2021, стр. 659-661.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{3f772b863e0a49a6850ff35d0e1eb4a2,

title = "Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors",

abstract = "Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.",

keywords = "amide, biodistribution, BNCT, closo-carborane, liposomes, toxicity, U87 tumor model",

author = "Tsygankova, {Alphiya R.} and Gruzdev, {Dmitry A.} and Kanygin, {Vladimir V.} and {Ya. Guselnikova}, Tatiana and Telegina, {Angelina A.} and Kasatova, {Anna I.} and Kichigin, {Aleksandr I.} and Levit, {Galina L.} and Mechetina, {Ludmila V.} and Mukhamadiyarov, {Rinat A.} and Razumov, {Ivan A.} and Solovieva, {Olga I.} and {Yu. Volkova}, Olga and Ponomarev, {Andrey A.} and Krasnovc, {Victor P.} and Zavjalova, {Evgenii L.}",

note = "Funding Information: The work was supported by the Russian Science Foundation (project no. 18-29-01007) in the part of preparation and investigation of the liposomes as well as biological tests, the State Assignment no. AAAA-A19-119012490007-8 in the part of the synthesis of the closo-carborane derivative as well as the Ministry of Science and Education of the Russian Federation (project no. 121031700315-2) in the part of ICP-AES analysis and examination of size/morphology of the liposomes. The authors are thankful to the Center for Shared Use {\textquoteleft}SPF-Vivarium{\textquoteright} of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences. The authors are also grateful to Dr. Elena I. Ryabchikova, Yuliya E. Poletaeva and Roman V. Sibirtsev for their assistance. Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = sep,

day = "1",

doi = "10.1016/j.mencom.2021.09.022",

language = "English",

volume = "31",

pages = "659--661",

journal = "Mendeleev Communications",

issn = "0959-9436",

publisher = "Elsevier",

number = "5",

}

RIS

TY - JOUR

T1 - Liposomes loaded with lipophilic derivative of closo-carborane as a potential boron delivery system for boron neutron capture therapy of tumors

AU - Tsygankova, Alphiya R.

AU - Gruzdev, Dmitry A.

AU - Kanygin, Vladimir V.

AU - Ya. Guselnikova, Tatiana

AU - Telegina, Angelina A.

AU - Kasatova, Anna I.

AU - Kichigin, Aleksandr I.

AU - Levit, Galina L.

AU - Mechetina, Ludmila V.

AU - Mukhamadiyarov, Rinat A.

AU - Razumov, Ivan A.

AU - Solovieva, Olga I.

AU - Yu. Volkova, Olga

AU - Ponomarev, Andrey A.

AU - Krasnovc, Victor P.

AU - Zavjalova, Evgenii L.

N1 - Funding Information: The work was supported by the Russian Science Foundation (project no. 18-29-01007) in the part of preparation and investigation of the liposomes as well as biological tests, the State Assignment no. AAAA-A19-119012490007-8 in the part of the synthesis of the closo-carborane derivative as well as the Ministry of Science and Education of the Russian Federation (project no. 121031700315-2) in the part of ICP-AES analysis and examination of size/morphology of the liposomes. The authors are thankful to the Center for Shared Use ‘SPF-Vivarium’ of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences. The authors are also grateful to Dr. Elena I. Ryabchikova, Yuliya E. Poletaeva and Roman V. Sibirtsev for their assistance. Publisher Copyright: © 2021

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.

AB - Liposomes encapsulated with lipophilic derivative of 1,2-dicarba-closo-dodecaborane have been obtained and tested for toxicity to glioblastoma U87 cells and biodistribution on a U87MG xenograft mouse model. The liposomes are able to penetrate the tumor and provide boron concentration up to 1.5 mmmmg g–1 with tumor-to-muscle ratio up to 2.4.

KW - amide

KW - biodistribution

KW - BNCT

KW - closo-carborane

KW - liposomes

KW - toxicity

KW - U87 tumor model

UR - http://www.scopus.com/inward/record.url?scp=85119520609&partnerID=8YFLogxK

U2 - 10.1016/j.mencom.2021.09.022

DO - 10.1016/j.mencom.2021.09.022

M3 - Article

AN - SCOPUS:85119520609

VL - 31

SP - 659

EP - 661

JO - Mendeleev Communications

JF - Mendeleev Communications

SN - 0959-9436

IS - 5

ER -

ID: 34706479