TY - JOUR

T1 - Lipins: Characteristics and functional role in the organism

AU - Saidakova, S. S.

AU - Morozova, K. N.

AU - Kiseleva, E. V.

N1 - This work was supported by grant no. 2019-0546 from the Ministry of Science and Higher Education of the Russian Federation (FSUS-2020-0040) and publicly funded project no. 0259-2021-0011 of the Institute of Cytology and Genetics SB RAS. Publisher Copyright: © 2021 Russian Academy of Sciences. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - The family of lipin proteins includes enzymes participating in the phospholipid biosynthesis pathway (Kennedy pathway) which are able to dephosphorylate phosphatidic acid to diacylglycerol. In addition, lipins may be transported from the cytoplasm to the nucleus and function as coactivators of gene expression. This dual function justifies the high interest in the study of these proteins. The purpose of this review is to give a general idea of the structure, functions, and regulation mechanisms of various lipin orthologs and isoforms in the tissues of eukaryotic organisms and to summarize the latest data obtained by researchers in this field. A separate section is devoted to human diseases caused by excess or deficiency of lipin.

AB - The family of lipin proteins includes enzymes participating in the phospholipid biosynthesis pathway (Kennedy pathway) which are able to dephosphorylate phosphatidic acid to diacylglycerol. In addition, lipins may be transported from the cytoplasm to the nucleus and function as coactivators of gene expression. This dual function justifies the high interest in the study of these proteins. The purpose of this review is to give a general idea of the structure, functions, and regulation mechanisms of various lipin orthologs and isoforms in the tissues of eukaryotic organisms and to summarize the latest data obtained by researchers in this field. A separate section is devoted to human diseases caused by excess or deficiency of lipin.

KW - Fld mice

KW - Lipids

KW - Lipin

KW - Lipodystrophy

KW - Phosphatidate phosphatase

KW - Transcriptional cofactor

UR - http://www.scopus.com/inward/record.url?scp=85107389575&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=44523575

UR - https://www.mendeley.com/catalogue/72124729-be95-3533-819e-448ba5145236/

U2 - 10.31857/S0041377121010090

DO - 10.31857/S0041377121010090

M3 - Review article

AN - SCOPUS:85107389575

VL - 63

SP - 17

EP - 29

JO - Цитология

JF - Цитология

SN - 0041-3771

IS - 1

M1 - 2

ER -