TY - JOUR

T1 - Limited Cheese Intake Paradigm Replaces Patterns of Behavioral Disorders in Experimental PTSD: Focus on Resveratrol Supplementation

AU - Tseilikman, Vadim E

AU - Shatilov, Vladislav A

AU - Zhukov, Maxim S

AU - Buksha, Irina A

AU - Epitashvily, Alexandr E

AU - Lipatov, Ilya A

AU - Aristov, Maxim R

AU - Koshelev, Alexandr G

AU - Karpenko, Marina N

AU - Traktirov, Dmitrii S

AU - Maistrenko, Viktoriya A

AU - Kamel, Mustapha

AU - Buhler, Alexey V

AU - Kovaleva, Elena G

AU - Kalinina, Tatyana S

AU - Pashkov, Anton A

AU - Kon'kov, Vadim V

AU - Novak, Jurica

AU - Tseilikman, Olga B

N1 - This work was supported by the Russian Scientific Foundation, Regional grant, Chelyabinsk Region (#23-15-20040).

PY - 2023/9/20

Y1 - 2023/9/20

N2 - Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD.

AB - Currently, the efficacy of drug therapy for post-traumatic stress disorder or PTSD leaves much to be desired, making nutraceutical support a promising avenue for treatment. Recent research has identified the protective effects of resveratrol in PTSD. Here, we tested the behavioral and neurobiological effects of combining cheese consumption with resveratrol supplements in an experimental PTSD model. Using the elevated plus maze test, we observed that cheese intake resulted in a shift from anxiety-like behavior to depressive behavior, evident in increased freezing acts. However, no significant changes in the anxiety index value were observed. Interestingly, supplementation with cheese and resveratrol only led to the elimination of freezing behavior in half of the PTSD rats. We further segregated the rats into two groups based on freezing behavior: Freezing+ and Freezing0 phenotypes. Resveratrol ameliorated the abnormalities in Monoamine Oxidize -A and Brain-Derived Neurotrophic Factor gene expression in the hippocampus, but only in the Freezing0 rats. Moreover, a negative correlation was found between the number of freezing acts and the levels of Monoamine Oxidize-A and Brain-Derived Neurotrophic Factor mRNAs in the hippocampus. The study results show promise for resveratrol supplementation in PTSD treatment. Further research is warranted to better understand the underlying mechanisms and optimize the potential benefits of resveratrol supplementation for PTSD.

KW - Animals

KW - Rats

KW - Stress Disorders, Post-Traumatic/drug therapy

KW - Brain-Derived Neurotrophic Factor/genetics

KW - Resveratrol/pharmacology

KW - Cheese

KW - Amines

KW - Dietary Supplements

KW - monoamines oxidize-A

KW - PTSD

KW - anxiety

KW - serotonin

KW - freezing

KW - brain-derived neurotrophic factor

KW - dopamine

KW - resveratrol

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85172768878&origin=inward&txGid=5a7dd451f67be6d4e8d615ae1ee2b941

UR - https://www.mendeley.com/catalogue/24638d7c-223c-3eca-a3cf-c2a0647ee65c/

U2 - 10.3390/ijms241814343

DO - 10.3390/ijms241814343

M3 - Article

C2 - 37762647

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 18

M1 - 14343

ER -