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Light-Stimulated Generation of Free Radicals by Quinones-Chelators. / Markova, Irina D.; Polyakov, Nikolay E.; Selyutina, Olga Yu и др.

в: Zeitschrift fur Physikalische Chemie, Том 231, № 2, 01.02.2017, стр. 369-389.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Markova, ID, Polyakov, NE, Selyutina, OY, Fedenok, LG, Fedotov, KY, Slepneva, IA, Leshina, TV, Pokrovsky, AG, Vasilieva, NV & Weiner, LM 2017, 'Light-Stimulated Generation of Free Radicals by Quinones-Chelators', Zeitschrift fur Physikalische Chemie, Том. 231, № 2, стр. 369-389. https://doi.org/10.1515/zpch-2016-0831

APA

Markova, I. D., Polyakov, N. E., Selyutina, O. Y., Fedenok, L. G., Fedotov, K. Y., Slepneva, I. A., Leshina, T. V., Pokrovsky, A. G., Vasilieva, N. V., & Weiner, L. M. (2017). Light-Stimulated Generation of Free Radicals by Quinones-Chelators. Zeitschrift fur Physikalische Chemie, 231(2), 369-389. https://doi.org/10.1515/zpch-2016-0831

Vancouver

Markova ID, Polyakov NE, Selyutina OY, Fedenok LG, Fedotov KY, Slepneva IA и др. Light-Stimulated Generation of Free Radicals by Quinones-Chelators. Zeitschrift fur Physikalische Chemie. 2017 февр. 1;231(2):369-389. doi: 10.1515/zpch-2016-0831

Author

Markova, Irina D. ; Polyakov, Nikolay E. ; Selyutina, Olga Yu и др. / Light-Stimulated Generation of Free Radicals by Quinones-Chelators. в: Zeitschrift fur Physikalische Chemie. 2017 ; Том 231, № 2. стр. 369-389.

BibTeX

@article{d6b9f1394335473697b677677b293ed4,
title = "Light-Stimulated Generation of Free Radicals by Quinones-Chelators",
abstract = "The role of metal ions in the mechanism of light-stimulated redox activity of potential anticancer agent 2-phenyl-4-(butylamino)naphtha[2,3-h]quinoline-7,12-dione (Qc) has been studied by CIDNP (chemically induced dynamic nuclear polarization) and EPR methods. The photo-induced oxidation of NADH and its synthetic analog-substituted dihydropyridine (DHP)-by quinone Qc was used as a model. The Qc capability of producing chelating complexes with divalent metal ions of Fe, Zn and Ca was studied quantitatively by optical absorption spectroscopy. A significant decrease of electrochemical reduction potential of Qc (ΔE=0.4-0.6 eV for ACN and ACN/PBS solutions) in chelating complexes and in protonated form of Qc was observed. A pronounced increase in efficiency of DHP oxidation in chelating complexes with Zn2+ and Ca2+ ions compared with free Qc was demonstrated. The yields of free radicals, including reactive oxygen species (ROS) and reaction products, were a few times higher than those in the absence of metal ions. Application of such chelating compounds to enhance ROS generation looks very promising for anti-cancer therapy, including the photodynamic therapy.",
keywords = "CIDNP, EPR, free radicals, metal chelation, photosynthetizers, quinones, spin traps, OXIDATIVE STRESS, NADH ANALOGS, PHOTOINDUCED ELECTRON-TRANSFER, MECHANISMS, PHOTO-CIDNP, CANCER, HYDROXYL RADICALS, PARAMAGNETIC-RESONANCE, ANTICANCER, 1,4-DIHYDROPYRIDINES",
author = "Markova, {Irina D.} and Polyakov, {Nikolay E.} and Selyutina, {Olga Yu} and Fedenok, {Lidia G.} and Fedotov, {Kirill Yu} and Slepneva, {Irina A.} and Leshina, {Tatyana V.} and Pokrovsky, {Andrey G.} and Vasilieva, {Nadezhda V.} and Weiner, {Lev M.}",
year = "2017",
month = feb,
day = "1",
doi = "10.1515/zpch-2016-0831",
language = "English",
volume = "231",
pages = "369--389",
journal = "Zeitschrift fur Physikalische Chemie",
issn = "0942-9352",
publisher = "Walter de Gruyter GmbH",
number = "2",

}

RIS

TY - JOUR

T1 - Light-Stimulated Generation of Free Radicals by Quinones-Chelators

AU - Markova, Irina D.

AU - Polyakov, Nikolay E.

AU - Selyutina, Olga Yu

AU - Fedenok, Lidia G.

AU - Fedotov, Kirill Yu

AU - Slepneva, Irina A.

AU - Leshina, Tatyana V.

AU - Pokrovsky, Andrey G.

AU - Vasilieva, Nadezhda V.

AU - Weiner, Lev M.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - The role of metal ions in the mechanism of light-stimulated redox activity of potential anticancer agent 2-phenyl-4-(butylamino)naphtha[2,3-h]quinoline-7,12-dione (Qc) has been studied by CIDNP (chemically induced dynamic nuclear polarization) and EPR methods. The photo-induced oxidation of NADH and its synthetic analog-substituted dihydropyridine (DHP)-by quinone Qc was used as a model. The Qc capability of producing chelating complexes with divalent metal ions of Fe, Zn and Ca was studied quantitatively by optical absorption spectroscopy. A significant decrease of electrochemical reduction potential of Qc (ΔE=0.4-0.6 eV for ACN and ACN/PBS solutions) in chelating complexes and in protonated form of Qc was observed. A pronounced increase in efficiency of DHP oxidation in chelating complexes with Zn2+ and Ca2+ ions compared with free Qc was demonstrated. The yields of free radicals, including reactive oxygen species (ROS) and reaction products, were a few times higher than those in the absence of metal ions. Application of such chelating compounds to enhance ROS generation looks very promising for anti-cancer therapy, including the photodynamic therapy.

AB - The role of metal ions in the mechanism of light-stimulated redox activity of potential anticancer agent 2-phenyl-4-(butylamino)naphtha[2,3-h]quinoline-7,12-dione (Qc) has been studied by CIDNP (chemically induced dynamic nuclear polarization) and EPR methods. The photo-induced oxidation of NADH and its synthetic analog-substituted dihydropyridine (DHP)-by quinone Qc was used as a model. The Qc capability of producing chelating complexes with divalent metal ions of Fe, Zn and Ca was studied quantitatively by optical absorption spectroscopy. A significant decrease of electrochemical reduction potential of Qc (ΔE=0.4-0.6 eV for ACN and ACN/PBS solutions) in chelating complexes and in protonated form of Qc was observed. A pronounced increase in efficiency of DHP oxidation in chelating complexes with Zn2+ and Ca2+ ions compared with free Qc was demonstrated. The yields of free radicals, including reactive oxygen species (ROS) and reaction products, were a few times higher than those in the absence of metal ions. Application of such chelating compounds to enhance ROS generation looks very promising for anti-cancer therapy, including the photodynamic therapy.

KW - CIDNP

KW - EPR

KW - free radicals

KW - metal chelation

KW - photosynthetizers

KW - quinones

KW - spin traps

KW - OXIDATIVE STRESS

KW - NADH ANALOGS

KW - PHOTOINDUCED ELECTRON-TRANSFER

KW - MECHANISMS

KW - PHOTO-CIDNP

KW - CANCER

KW - HYDROXYL RADICALS

KW - PARAMAGNETIC-RESONANCE

KW - ANTICANCER

KW - 1,4-DIHYDROPYRIDINES

UR - http://www.scopus.com/inward/record.url?scp=85012164094&partnerID=8YFLogxK

U2 - 10.1515/zpch-2016-0831

DO - 10.1515/zpch-2016-0831

M3 - Article

AN - SCOPUS:85012164094

VL - 231

SP - 369

EP - 389

JO - Zeitschrift fur Physikalische Chemie

JF - Zeitschrift fur Physikalische Chemie

SN - 0942-9352

IS - 2

ER -

ID: 8686754