TY - JOUR

T1 - Interactome of Base and Nucleotide Excision DNA Repair Systems

AU - Rechkunova, N. I.

AU - Krasikova, Y. S.

AU - Lavrik, O. I.

N1 - Funding Information: The work was supported by grant from the Russian Science Foundation (no. 19-14-00107) and the Program of Fundamental Scientific Research of the State Academies of Sciences (no. 0245-2021-0009). Publisher Copyright: © 2021, Pleiades Publishing, Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - The base and nucleotide excision DNA repair (BER and NER) systems are aimed at removing specific types of damaged DNA, i.e., oxidized, alkylated, or deaminated bases in the case of BER and bulky damage caused by UV radiation or chemical carcinogens in the case of NER. In some cases, however, the repair process follows a more complex scenario, which implies that the repair pathways exchange proteins and interact with each other to form a common interactome. This review describes the BER and NER mechanisms and discusses the current data on the involvement of the NER proteins in the repair of DNA lesions caused by oxidative stress and the BER proteins in the removal of bulky DNA adducts. We also discuss the role of poly(ADP-ribose) polymerase 1 in the regulation of the BER and NER processes and their coordination in the repair of complex (cluster) lesions.

AB - The base and nucleotide excision DNA repair (BER and NER) systems are aimed at removing specific types of damaged DNA, i.e., oxidized, alkylated, or deaminated bases in the case of BER and bulky damage caused by UV radiation or chemical carcinogens in the case of NER. In some cases, however, the repair process follows a more complex scenario, which implies that the repair pathways exchange proteins and interact with each other to form a common interactome. This review describes the BER and NER mechanisms and discusses the current data on the involvement of the NER proteins in the repair of DNA lesions caused by oxidative stress and the BER proteins in the removal of bulky DNA adducts. We also discuss the role of poly(ADP-ribose) polymerase 1 in the regulation of the BER and NER processes and their coordination in the repair of complex (cluster) lesions.

KW - DNA repair

KW - protein-protein interactions

KW - regulation of DNA repair processes

UR - http://www.scopus.com/inward/record.url?scp=85104965614&partnerID=8YFLogxK

U2 - 10.1134/S0026893321020126

DO - 10.1134/S0026893321020126

M3 - Review article

AN - SCOPUS:85104965614

VL - 55

SP - 155

EP - 166

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 2

ER -