TY - JOUR

T1 - Immunogenic Cell Death in Cancer Therapy

AU - Troitskaya, O. S.

AU - Novak, D. D.

AU - Richter, V. A.

AU - Koval, O. A.

N1 - Funding Information: This review was prepared with the support of the Russian Foundation for Basic Research (RFBR) No. 19-34-90134 (Postgraduate students), the Russian Science Foundation (RSF) No. 19-19-00255 and the project of basic budget financing of the Ministry of Science and Higher Education of the Russian Federation No. 0245-2019-0001. Publisher Copyright: © 2022 National Research University Higher School of Economics. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2022/4/21

Y1 - 2022/4/21

N2 - Apoptosis plays a crucial role in chemotherapy-induced cell death. The conventional theory holding that apoptosis needs to be immunologically silent has recently been revised, and the concept of immunogenic cell death (ICD) has been proposed. This review describes the main features of ICD induction. These ICD markers are important for the effectiveness of anticancer therapy, as well as for basic research into cell death regulation. The mechanism of the “vaccination effect” of dying cancer cells undergoing ICD has been fully described, including the activation of specific antitumor response after re-challenge by the same living tumor cells. This review also discusses the whole set of molecular events attributing cell death to immunogenic type: the exposure of calreticulin and the heat shock protein HSP70 to the outer surface of the cell membrane and the release of the nuclear protein HMGB1 and ATP into the extracellular space. ICD inducers of various nature (chemotherapy drugs, cytotoxic proteins, and oncolytic viruses), as well as physical methods, are classified in the current review.

AB - Apoptosis plays a crucial role in chemotherapy-induced cell death. The conventional theory holding that apoptosis needs to be immunologically silent has recently been revised, and the concept of immunogenic cell death (ICD) has been proposed. This review describes the main features of ICD induction. These ICD markers are important for the effectiveness of anticancer therapy, as well as for basic research into cell death regulation. The mechanism of the “vaccination effect” of dying cancer cells undergoing ICD has been fully described, including the activation of specific antitumor response after re-challenge by the same living tumor cells. This review also discusses the whole set of molecular events attributing cell death to immunogenic type: the exposure of calreticulin and the heat shock protein HSP70 to the outer surface of the cell membrane and the release of the nuclear protein HMGB1 and ATP into the extracellular space. ICD inducers of various nature (chemotherapy drugs, cytotoxic proteins, and oncolytic viruses), as well as physical methods, are classified in the current review.

KW - Antitumor vaccination

KW - Apoptosis-inducing proteins

KW - Calreticulin

KW - Chemotherapy

KW - Cold plasma jet.

KW - Hmgb1

KW - Immunogenic cell death (icd)

KW - Oncolytic viruses

UR - http://www.scopus.com/inward/record.url?scp=85130491955&partnerID=8YFLogxK

UR - https://elibrary.ru/item.asp?id=48433846

UR - https://www.mendeley.com/catalogue/03ca0c3c-6bef-33d9-920e-4e5b439e490c/

U2 - 10.32607/actanaturae.11523

DO - 10.32607/actanaturae.11523

M3 - Article

C2 - 35441043

AN - SCOPUS:85130491955

VL - 14

SP - 40

EP - 53

JO - Acta Naturae

JF - Acta Naturae

SN - 2075-8251

IS - 1

M1 - 4

ER -