TY - JOUR

T1 - Hypotensive Effects of Arginase Inhibition by L-Norvaline in Genetic Models of Normotensive and Hypertensive Rats

AU - Gilinsky, M A

AU - Polityko, Yu K

AU - Markel, A L

AU - Aftanas, L I

N1 - © 2023. Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2023/4/13

Y1 - 2023/4/13

N2 - The main effect of arginase inhibition after administration of L-norvaline is a decrease in BP. At the same time, norvaline causes various side effects in normotensive and hypertensive animals. In our experiments, L-norvaline was administered intraperitoneally (30 mg/kg) for 7 days to normotensive WAG rats (Wistar Albino Glaxo) and hypertensive ISIAH rats (Inherited, Stress-Induced Arterial Hypertension). In ISIAH rats, BP decrease was accompanied by an increase in diuresis, while in WAG rats, diuresis remained unchanged or little changed. At the same time, hypertensive rats demonstrated an increase of catecholamine content in the adrenal glands, while in normotensive animals, it was decreased. The differences in the effects of norvaline can be associated with different mechanisms of BP maintenance in normotensive and hypertensive animals. Normally, BP is maintained by the regulatory influences of the nitric oxide system. In hypertension, this system is weakened, and the hypotensive effects are probably achieved via increased diuresis.

AB - The main effect of arginase inhibition after administration of L-norvaline is a decrease in BP. At the same time, norvaline causes various side effects in normotensive and hypertensive animals. In our experiments, L-norvaline was administered intraperitoneally (30 mg/kg) for 7 days to normotensive WAG rats (Wistar Albino Glaxo) and hypertensive ISIAH rats (Inherited, Stress-Induced Arterial Hypertension). In ISIAH rats, BP decrease was accompanied by an increase in diuresis, while in WAG rats, diuresis remained unchanged or little changed. At the same time, hypertensive rats demonstrated an increase of catecholamine content in the adrenal glands, while in normotensive animals, it was decreased. The differences in the effects of norvaline can be associated with different mechanisms of BP maintenance in normotensive and hypertensive animals. Normally, BP is maintained by the regulatory influences of the nitric oxide system. In hypertension, this system is weakened, and the hypotensive effects are probably achieved via increased diuresis.

KW - Rats

KW - Animals

KW - Arginase

KW - Models, Genetic

KW - Rats, Wistar

KW - Hypertension

KW - Blood Pressure/physiology

KW - catecholamines

KW - L-norvaline

KW - adrenal glands

KW - hypertension

KW - arginase

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152520674&origin=inward

UR - https://www.mendeley.com/catalogue/23b511a5-3544-30f5-a756-46880cc6fab9/

U2 - 10.1007/s10517-023-05767-5

DO - 10.1007/s10517-023-05767-5

M3 - Article

C2 - 37046117

VL - 174

SP - 674

EP - 677

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 5

ER -