TY - JOUR

T1 - Hyperthermal Effect of Infrared Irradiation on Aqueous Dispersion of Carbon Nanotubes and Their Penetration Into Drosophila melanogaster Larvae

AU - Gurova, Olga A.

AU - Dubatolova, Tatyana D.

AU - Shlyakhova, Elena V.

AU - Omelyanchuk, Leonid V.

AU - Okotrub, Alexander V.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Dispersions of chemically modified multi-walled carbon nanotubes (MWCNTs) are investigated by interacting of near-infrared (NIR) laser irradiation power of 500 mW to determine the efficiency of heating. The resulting dispersions with modified CNTs are fed into the larva of Drosophila melanogaster, containing green fluorescent protein (GFP) reporter whose expression (synthesis of protein) is activated by hsp70 promoter. After NIR irradiation, it is found that organs of larvae gave GFP signal. The presence of a signal is associated with heating of organs to the heat shock temperature due to CNTs penetration. Thus, the experiment provides validation that nanotubes can penetrate into living Drosophila body. It is shown that the CNTs length and modification affect the penetration efficiency.

AB - Dispersions of chemically modified multi-walled carbon nanotubes (MWCNTs) are investigated by interacting of near-infrared (NIR) laser irradiation power of 500 mW to determine the efficiency of heating. The resulting dispersions with modified CNTs are fed into the larva of Drosophila melanogaster, containing green fluorescent protein (GFP) reporter whose expression (synthesis of protein) is activated by hsp70 promoter. After NIR irradiation, it is found that organs of larvae gave GFP signal. The presence of a signal is associated with heating of organs to the heat shock temperature due to CNTs penetration. Thus, the experiment provides validation that nanotubes can penetrate into living Drosophila body. It is shown that the CNTs length and modification affect the penetration efficiency.

KW - absorption spectra

KW - Drosophila melanogaster

KW - green fluorescent protein reporters

KW - larvae

KW - multiwalled carbon nanotubes

KW - thermal properties

KW - FUNCTIONALIZATION

KW - THERAPY

KW - GRAPHENE

KW - THERMAL-CONDUCTIVITY

KW - INORGANIC NANOPARTICLES

UR - http://www.scopus.com/inward/record.url?scp=85040784066&partnerID=8YFLogxK

U2 - 10.1002/pssb.201700264

DO - 10.1002/pssb.201700264

M3 - Article

AN - SCOPUS:85040784066

VL - 255

JO - Physica Status Solidi (B): Basic Research

JF - Physica Status Solidi (B): Basic Research

SN - 0370-1972

IS - 1

M1 - 1700264

ER -