TY - JOUR

T1 - Hyperpolarization of [13C]formate using parahydrogen

AU - Burueva, Dudari B.

AU - Sviyazov, Sergey V.

AU - Chukanov, Nikita V.

AU - Mustafin, Nazim R.

AU - Salnikov, Oleg G.

AU - Chekmenev, Eduard Y.

AU - Kovtunov, Kirill V.

AU - Koptyug, Igor V.

N1 - DBB thanks the Russian Science Foundation (grant number 23-23-00394 ) for supporting PHIP experiments.

PY - 2024/12

Y1 - 2024/12

N2 - Sodium [13C]formate was successfully hyperpolarized using parahydrogen-induced polarization by means of side-arm hydrogenation (PHIP-SAH). Allyl [13C]formate was hyperpolarized using homogeneous hydrogenation of the corresponding unsaturated precursor (propargyl [13C]formate) in acetone-d6 with parahydrogen. The observed proton polarization was estimated as 16.6 ± 0.6 % while achieving 80 % chemical conversion. The 1H-to-13C polarization transfer was performed using magnetic field cycling. The highest observed polarization for 13C nuclei was estimated as 1.7 ± 0.2 % and was obtained at 250 nT polarization transfer magnetic field. We demonstrate that the 13C hyperpolarization is retained during the hydrolysis of allyl [13C]formate and hyperpolarized sodium [13C]formate was produced with P13C of 0.4 ± 0.1 %.

AB - Sodium [13C]formate was successfully hyperpolarized using parahydrogen-induced polarization by means of side-arm hydrogenation (PHIP-SAH). Allyl [13C]formate was hyperpolarized using homogeneous hydrogenation of the corresponding unsaturated precursor (propargyl [13C]formate) in acetone-d6 with parahydrogen. The observed proton polarization was estimated as 16.6 ± 0.6 % while achieving 80 % chemical conversion. The 1H-to-13C polarization transfer was performed using magnetic field cycling. The highest observed polarization for 13C nuclei was estimated as 1.7 ± 0.2 % and was obtained at 250 nT polarization transfer magnetic field. We demonstrate that the 13C hyperpolarization is retained during the hydrolysis of allyl [13C]formate and hyperpolarized sodium [13C]formate was produced with P13C of 0.4 ± 0.1 %.

KW - hyperpolarization · parahydrogen · PHIP-SAH · formate

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85209763408&origin=inward&txGid=96654a3e84d0cff8019b2d74ee355d91

UR - https://www.mendeley.com/catalogue/17177dd1-22a7-3bfb-8b30-7537c4917b23/

U2 - 10.1016/j.jmro.2024.100176

DO - 10.1016/j.jmro.2024.100176

M3 - Article

VL - 21

JO - Journal of Magnetic Resonance Open

JF - Journal of Magnetic Resonance Open

SN - 2666-4410

M1 - 100176

ER -