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Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. / Ermakov, Evgeny A.; Ivanova, Svetlana A.; Buneva, Valentina N. и др.

в: IUBMB Life, Том 70, № 2, 01.02.2018, стр. 153-164.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Ermakov, EA, Ivanova, SA, Buneva, VN & Nevinsky, GA 2018, 'Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia', IUBMB Life, Том. 70, № 2, стр. 153-164. https://doi.org/10.1002/iub.1712

APA

Ermakov, E. A., Ivanova, S. A., Buneva, V. N., & Nevinsky, G. A. (2018). Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. IUBMB Life, 70(2), 153-164. https://doi.org/10.1002/iub.1712

Vancouver

Ermakov EA, Ivanova SA, Buneva VN, Nevinsky GA. Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. IUBMB Life. 2018 февр. 1;70(2):153-164. doi: 10.1002/iub.1712

Author

Ermakov, Evgeny A. ; Ivanova, Svetlana A. ; Buneva, Valentina N. и др. / Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia. в: IUBMB Life. 2018 ; Том 70, № 2. стр. 153-164.

BibTeX

@article{2a786991559348f68a30aca95b36dd80,
title = "Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia",
abstract = "Significant importance of autoimmune changes in the pathogenesis of schizophrenia (SCZ) is not established. Here, we present the first evidence that autoantibodies of 100% SCZ patients possess RNase activity: сCMP > poly(C) > poly(A) > yeast RNA. In addition, we have got an unexpected result: there was revealed site-specific hydrolysis of four known SCZ specific microRNAs (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p) playing an important role in the regulation of several genes functioning. Three major of cleavage sites are located in the microRNA loops or duplex parts directly articulated with the loops. RNase abzymes can contribute to decreasing of microRNAs effects on the functioning of numerous genes and the products of their transcription. Therefore, abzymes with RNase activity may be to some extent important for the development of schizophrenia.",
keywords = "abzymes, autoimmune reactions, microRNA hydrolysis, schizophrenia, SYNAPTIC PROTEINS, ANTIBODIES, SYSTEMIC-LUPUS-ERYTHEMATOSUS, LIGHT-CHAIN, RISK, MYELIN BASIC-PROTEIN, IMMUNE-SYSTEM, PANCREATIC RIBONUCLEASE-A, MOLECULAR-CLONING, ABERRANT EXPRESSION, Immune Sera, Humans, Middle Aged, Male, Adult, Female, Schizophrenia/genetics, Hydrolysis, Immunoglobulin G/isolation & purification, Autoantibodies/metabolism, MicroRNAs/metabolism",
author = "Ermakov, {Evgeny A.} and Ivanova, {Svetlana A.} and Buneva, {Valentina N.} and Nevinsky, {Georgy A.}",
note = "{\textcopyright} 2018 International Union of Biochemistry and Molecular Biology.",
year = "2018",
month = feb,
day = "1",
doi = "10.1002/iub.1712",
language = "English",
volume = "70",
pages = "153--164",
journal = "IUBMB Life",
issn = "1521-6543",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia

AU - Ermakov, Evgeny A.

AU - Ivanova, Svetlana A.

AU - Buneva, Valentina N.

AU - Nevinsky, Georgy A.

N1 - © 2018 International Union of Biochemistry and Molecular Biology.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Significant importance of autoimmune changes in the pathogenesis of schizophrenia (SCZ) is not established. Here, we present the first evidence that autoantibodies of 100% SCZ patients possess RNase activity: сCMP > poly(C) > poly(A) > yeast RNA. In addition, we have got an unexpected result: there was revealed site-specific hydrolysis of four known SCZ specific microRNAs (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p) playing an important role in the regulation of several genes functioning. Three major of cleavage sites are located in the microRNA loops or duplex parts directly articulated with the loops. RNase abzymes can contribute to decreasing of microRNAs effects on the functioning of numerous genes and the products of their transcription. Therefore, abzymes with RNase activity may be to some extent important for the development of schizophrenia.

AB - Significant importance of autoimmune changes in the pathogenesis of schizophrenia (SCZ) is not established. Here, we present the first evidence that autoantibodies of 100% SCZ patients possess RNase activity: сCMP > poly(C) > poly(A) > yeast RNA. In addition, we have got an unexpected result: there was revealed site-specific hydrolysis of four known SCZ specific microRNAs (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p) playing an important role in the regulation of several genes functioning. Three major of cleavage sites are located in the microRNA loops or duplex parts directly articulated with the loops. RNase abzymes can contribute to decreasing of microRNAs effects on the functioning of numerous genes and the products of their transcription. Therefore, abzymes with RNase activity may be to some extent important for the development of schizophrenia.

KW - abzymes

KW - autoimmune reactions

KW - microRNA hydrolysis

KW - schizophrenia

KW - SYNAPTIC PROTEINS

KW - ANTIBODIES

KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS

KW - LIGHT-CHAIN

KW - RISK

KW - MYELIN BASIC-PROTEIN

KW - IMMUNE-SYSTEM

KW - PANCREATIC RIBONUCLEASE-A

KW - MOLECULAR-CLONING

KW - ABERRANT EXPRESSION

KW - Immune Sera

KW - Humans

KW - Middle Aged

KW - Male

KW - Adult

KW - Female

KW - Schizophrenia/genetics

KW - Hydrolysis

KW - Immunoglobulin G/isolation & purification

KW - Autoantibodies/metabolism

KW - MicroRNAs/metabolism

UR - http://www.scopus.com/inward/record.url?scp=85040716746&partnerID=8YFLogxK

U2 - 10.1002/iub.1712

DO - 10.1002/iub.1712

M3 - Article

C2 - 29341394

AN - SCOPUS:85040716746

VL - 70

SP - 153

EP - 164

JO - IUBMB Life

JF - IUBMB Life

SN - 1521-6543

IS - 2

ER -

ID: 9327651