Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Hybrid system {W6I8}-cluster/dsDNA as an agent for targeted X-ray induced photodynamic therapy of cancer stem cells. / Pozmogova, Tatiana N.; Sitnikova, Natalya A.; Pronina, Ekaterina V. и др.
в: Materials Chemistry Frontiers, Том 5, № 20, 21.10.2021, стр. 7499-7507.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Hybrid system {W6I8}-cluster/dsDNA as an agent for targeted X-ray induced photodynamic therapy of cancer stem cells
AU - Pozmogova, Tatiana N.
AU - Sitnikova, Natalya A.
AU - Pronina, Ekaterina V.
AU - Miroshnichenko, Svetlana M.
AU - Kushnarenko, Andrey O.
AU - Solovieva, Anastasiya O.
AU - Bogachev, Sergey S.
AU - Vavilov, Georgy D.
AU - Efremova, Olga A.
AU - Vorotnikov, Yuri A.
AU - Shestopalov, Michael A.
N1 - Funding Information: This work was supported by the Russian Science Foundation (Grant No. 18-75-10060) (material synthesis and characterisation) and was performed as part of the state assignment No. 0259-2019-0007 (all biological experiments). MAS thanks the Russian Foundation for Basic Research (Grant No. 20-33-90087). The NIIC team thanks the Ministry of Science and Education of the Russian Federation, No. 121031700321-3. This work involved the use of equipment from the Multi-Access Center ‘‘Spectrometric measurements’’ (Institute of Biochemistry, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia). Publisher Copyright: © 2021 the Partner Organisations.
PY - 2021/10/21
Y1 - 2021/10/21
N2 - Metastasis is one of the leading causes of the recurrence and high mortality of cancer. According to a recent hierarchical model of tumour formation, cancer stem cells (CSCs) are responsible for the occurrence of metastases and cancer relapse. Unfortunately, these cells are believed to have high resistance to conventional treatments. The development of therapies focused on the targeted elimination of cancer stem cells is now viewed as a new and advantageous approach to cancer treatment. Here we present a new material-a hybrid of double-stranded DNA (dsDNA) and hexatungsten iodide octahedral cluster {W6I8}4+-as an effective agent for the targeted X-ray induced photodynamic therapy (X-PDT) of cancer stem cells. Specifically, our approach was to employ an intrinsic property of CSCs to selectively internalise dsDNA molecules to drag {W6I8}, scintillating and photosensitising moieties, directly into CSCs. The hybrid material has high stability in aqueous media, low cytotoxicity in the absence of irradiation, and significant selective cellular uptake by CSCs. X-Ray irradiation of CSCs incubated with the material resulted in an extremely low growth rate of the solid tumour in model CBA mice.
AB - Metastasis is one of the leading causes of the recurrence and high mortality of cancer. According to a recent hierarchical model of tumour formation, cancer stem cells (CSCs) are responsible for the occurrence of metastases and cancer relapse. Unfortunately, these cells are believed to have high resistance to conventional treatments. The development of therapies focused on the targeted elimination of cancer stem cells is now viewed as a new and advantageous approach to cancer treatment. Here we present a new material-a hybrid of double-stranded DNA (dsDNA) and hexatungsten iodide octahedral cluster {W6I8}4+-as an effective agent for the targeted X-ray induced photodynamic therapy (X-PDT) of cancer stem cells. Specifically, our approach was to employ an intrinsic property of CSCs to selectively internalise dsDNA molecules to drag {W6I8}, scintillating and photosensitising moieties, directly into CSCs. The hybrid material has high stability in aqueous media, low cytotoxicity in the absence of irradiation, and significant selective cellular uptake by CSCs. X-Ray irradiation of CSCs incubated with the material resulted in an extremely low growth rate of the solid tumour in model CBA mice.
UR - http://www.scopus.com/inward/record.url?scp=85117024621&partnerID=8YFLogxK
U2 - 10.1039/d1qm00956g
DO - 10.1039/d1qm00956g
M3 - Article
AN - SCOPUS:85117024621
VL - 5
SP - 7499
EP - 7507
JO - Materials Chemistry Frontiers
JF - Materials Chemistry Frontiers
SN - 2052-1537
IS - 20
ER -
ID: 34422724