Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy. / Pashkina, Ekaterina; Bykova, Maria; Berishvili, Maria и др.
в: Cells, Том 14, № 2, 61, 07.01.2025.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy
AU - Pashkina, Ekaterina
AU - Bykova, Maria
AU - Berishvili, Maria
AU - Lazarev, Yaroslav
AU - Kozlov, Vladimir
N1 - This study was funded by the Russian Science Foundation according to research project No. 23-25-00375.
PY - 2025/1/7
Y1 - 2025/1/7
N2 - In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells. This review examines the role of HA and its receptors in health and tumors and analyzes existing HA-based delivery systems and their use in various types of cancer. The development of new HA-based drug delivery systems will bring new opportunities and challenges to anti-cancer therapy.
AB - In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells. This review examines the role of HA and its receptors in health and tumors and analyzes existing HA-based delivery systems and their use in various types of cancer. The development of new HA-based drug delivery systems will bring new opportunities and challenges to anti-cancer therapy.
KW - cancer therapy
KW - drug delivery system
KW - extracellular matrix
KW - hyaluronic acid
KW - nanoparticle
KW - supramolecular system
UR - https://www.mendeley.com/catalogue/bd04ed8e-d6ea-396b-a85a-c43c806ea97e/
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85215966185&origin=inward&txGid=e32b8bbc40f8b51dd55ed2e3d223a102
U2 - 10.3390/cells14020061
DO - 10.3390/cells14020061
M3 - Article
C2 - 39851489
VL - 14
JO - Cells
JF - Cells
SN - 2073-4409
IS - 2
M1 - 61
ER -
ID: 63690260