TY - JOUR

T1 - Human Genetic Predisposition to Diseases Caused by Viruses from Flaviviridae Family

AU - Yudin, N. S.

AU - Barkhash, A. V.

AU - Maksimov, V. N.

AU - Ignatieva, E. V.

AU - Romaschenko, A. G.

PY - 2018/4/27

Y1 - 2018/4/27

N2 - The identification of human predisposition genes to severe forms of infectious diseases is important for understanding the mechanisms of pathogenesis, as well as for the detection of the risk groups. This will allow one to carry out targeted vaccination and preventive therapy. The most common approaches to the genetic risk estimation include conducting association studies, in which the groups of patients and control individuals are compared using both preliminarily selected candidate genes and using genome-wide analysis. To search for genetic variants predisposed to severe forms of infectious diseases, it is expedient to form a control that consists of patients with clinically proven infections with asymptomatic or mild forms of the disease. The examples of the use of these approaches to identify genetic factors that predispose one to severe forms of infections caused by viruses from the Flaviviridae family are considered in the review. At present, a number of genetic markers associated with predisposition to tick-borne encephalitis, West Nile fever, and Dengue fever have already been detected. These associations must be confirmed in independent samples. Genetic variants, for which the association with spontaneous recovery during infection with hepatitis C virus, patient's reaction on antiviral drugs, and the development of liver fibrosis was established, were also detected. The gene variants with more pronounced phenotypic effects will probably be found during further studies; they can be used in clinical practice as prognostic markers of the course and outcomes of infection with the Flaviviridae, as well as of the response to treatment.

AB - The identification of human predisposition genes to severe forms of infectious diseases is important for understanding the mechanisms of pathogenesis, as well as for the detection of the risk groups. This will allow one to carry out targeted vaccination and preventive therapy. The most common approaches to the genetic risk estimation include conducting association studies, in which the groups of patients and control individuals are compared using both preliminarily selected candidate genes and using genome-wide analysis. To search for genetic variants predisposed to severe forms of infectious diseases, it is expedient to form a control that consists of patients with clinically proven infections with asymptomatic or mild forms of the disease. The examples of the use of these approaches to identify genetic factors that predispose one to severe forms of infections caused by viruses from the Flaviviridae family are considered in the review. At present, a number of genetic markers associated with predisposition to tick-borne encephalitis, West Nile fever, and Dengue fever have already been detected. These associations must be confirmed in independent samples. Genetic variants, for which the association with spontaneous recovery during infection with hepatitis C virus, patient's reaction on antiviral drugs, and the development of liver fibrosis was established, were also detected. The gene variants with more pronounced phenotypic effects will probably be found during further studies; they can be used in clinical practice as prognostic markers of the course and outcomes of infection with the Flaviviridae, as well as of the response to treatment.

KW - candidate gene

KW - Dengue virus

KW - Flaviviridae

KW - genome-wide association analysis

KW - genomics

KW - hepatitis C virus

KW - tick-borne encephalitis

KW - West Nile virus

KW - Flaviviridae

KW - Flaviviridae Infections/genetics

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

UR - http://www.scopus.com/inward/record.url?scp=85055080375&partnerID=8YFLogxK

U2 - 10.7868/S0026898418020039

DO - 10.7868/S0026898418020039

M3 - Review article

C2 - 29695688

AN - SCOPUS:85055080375

VL - 52

SP - 190

EP - 209

JO - Molekulyarnaya Biologiya

JF - Molekulyarnaya Biologiya

SN - 0026-8984

IS - 2

ER -