TY - JOUR

T1 - Hippocampal Subfield Abnormalities in Patients With Primary Trigeminal Neuralgia

AU - Filimonova, Elena

AU - Pashkov, Anton

AU - Moysak, Galina

AU - Martirosyan, Azniv

AU - Rzaev, Jamil

PY - 2025/2/18

Y1 - 2025/2/18

N2 - Background and Purpose: Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder whose pathogenesis is not solely confined to the trigeminal system. Although substantial progress has been made in understanding the underlying mechanisms, comprehensive and consistent data concerning the involvement of the hippocampal formation in this process are lacking. The aim of this study was to evaluate structural changes in hippocampal subfields in patients with PTN. Methods: Fifty-nine individuals who were diagnosed with PTN and 28 healthy controls matched for age and sex underwent high-resolution 3 Tesla MRI. HippUnfold software was used for the segmentation of hippocampal subfields and the extraction of features. Covariance analyses were performed to analyze changes in the volume, thickness, and gyrification index of different subfields in patients with PTN compared to controls. Furthermore, the relationships between MR morphometry data and the severity of nerve root compression, as well as the intensity and duration of pain, were examined in patients with PTN. Results: Our analysis demonstrated a decrease in the volume of the right cornu ammonis subfield 1 (CA1)–CA3 and left CA2 hippocampal subfields in patients with PTN compared to healthy controls (adjusted p 

AB - Background and Purpose: Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder whose pathogenesis is not solely confined to the trigeminal system. Although substantial progress has been made in understanding the underlying mechanisms, comprehensive and consistent data concerning the involvement of the hippocampal formation in this process are lacking. The aim of this study was to evaluate structural changes in hippocampal subfields in patients with PTN. Methods: Fifty-nine individuals who were diagnosed with PTN and 28 healthy controls matched for age and sex underwent high-resolution 3 Tesla MRI. HippUnfold software was used for the segmentation of hippocampal subfields and the extraction of features. Covariance analyses were performed to analyze changes in the volume, thickness, and gyrification index of different subfields in patients with PTN compared to controls. Furthermore, the relationships between MR morphometry data and the severity of nerve root compression, as well as the intensity and duration of pain, were examined in patients with PTN. Results: Our analysis demonstrated a decrease in the volume of the right cornu ammonis subfield 1 (CA1)–CA3 and left CA2 hippocampal subfields in patients with PTN compared to healthy controls (adjusted p 

KW - HippUnfold

KW - MR morphometry

KW - hippocampus

KW - trigeminal neuralgia

KW - Reproducibility of Results

KW - Humans

KW - Middle Aged

KW - Male

KW - Magnetic Resonance Imaging/methods

KW - Hippocampus/diagnostic imaging

KW - Sensitivity and Specificity

KW - Female

KW - Adult

KW - Aged

KW - Trigeminal Neuralgia/diagnostic imaging

UR - https://www.mendeley.com/catalogue/1abc3380-5885-33b0-89fe-2ccf22a6dfe2/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85218968265&origin=inward&txGid=96944f651c1dc6f904701a3a3fa447e2

UR - https://pubmed.ncbi.nlm.nih.gov/39966338/

U2 - 10.1111/jon.70026

DO - 10.1111/jon.70026

M3 - Article

C2 - 39966338

VL - 35

SP - e70026

JO - Journal of Neuroimaging

JF - Journal of Neuroimaging

SN - 1552-6569

IS - 1

M1 - e70026

ER -