Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism. / Romashev, Nikolai F.; Abramov, Pavel A.; Bakaev, Ivan V. и др.
в: Inorganic Chemistry, Том 61, № 4, 31.01.2022, стр. 2105-2118.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism
AU - Romashev, Nikolai F.
AU - Abramov, Pavel A.
AU - Bakaev, Ivan V.
AU - Fomenko, Iakov S.
AU - Samsonenko, Denis G.
AU - Novikov, Alexander S.
AU - Tong, Kelvin K.H.
AU - Ahn, Dohyun
AU - Dorovatovskii, Pavel V.
AU - Zubavichus, Yan V.
AU - Ryadun, Aleksey A.
AU - Patutina, Olga A.
AU - Sokolov, Maxim N.
AU - Babak, Maria V.
AU - Gushchin, Artem L.
N1 - Publisher Copyright: © 2022 American Chemical Society
PY - 2022/1/31
Y1 - 2022/1/31
N2 - A series of heteroleptic square-planar Pt and Pd complexes with bis(diisopropylphenyl) iminoacenaphtene (dpp-Bian) and Cl, 1,3-dithia-2-thione-4,5-dithiolate (dmit), or 1,3-dithia-2-thione-4,5-diselenolate (dsit) ligands have been prepared and characterized by spectroscopic techniques, elemental analysis, X-ray diffraction analysis, and cyclic voltammetry (CV). The intermolecular noncovalent interactions in the crystal structures were assessed by density functional theory (DFT) calculations. The anticancer activity of Pd complexes in breast cancer cell lines was limited by their solubility. Pd(dpp-Bian) complexes with dmit and dsit ligands as well as an uncoordinated dpp-Bian ligand were devoid of cytotoxicity, while the [Pd(dpp-Bian)Cl2] complex was cytotoxic. On the contrary, all Pt(dpp-Bian) complexes demonstrated anticancer activity in a low micromolar concentration range, which was 8-20 times higher than the activity of cisplatin, and up to 2.5-fold selectivity toward cancer cells over healthy fibroblasts. The presence of a redox-active dpp-Bian ligand in Pt and Pd complexes resulted in the induction of reactive oxygen species (ROS) in cancer cells. In addition, these complexes were able to intercalate into DNA, indicating the dual mechanism of action.
AB - A series of heteroleptic square-planar Pt and Pd complexes with bis(diisopropylphenyl) iminoacenaphtene (dpp-Bian) and Cl, 1,3-dithia-2-thione-4,5-dithiolate (dmit), or 1,3-dithia-2-thione-4,5-diselenolate (dsit) ligands have been prepared and characterized by spectroscopic techniques, elemental analysis, X-ray diffraction analysis, and cyclic voltammetry (CV). The intermolecular noncovalent interactions in the crystal structures were assessed by density functional theory (DFT) calculations. The anticancer activity of Pd complexes in breast cancer cell lines was limited by their solubility. Pd(dpp-Bian) complexes with dmit and dsit ligands as well as an uncoordinated dpp-Bian ligand were devoid of cytotoxicity, while the [Pd(dpp-Bian)Cl2] complex was cytotoxic. On the contrary, all Pt(dpp-Bian) complexes demonstrated anticancer activity in a low micromolar concentration range, which was 8-20 times higher than the activity of cisplatin, and up to 2.5-fold selectivity toward cancer cells over healthy fibroblasts. The presence of a redox-active dpp-Bian ligand in Pt and Pd complexes resulted in the induction of reactive oxygen species (ROS) in cancer cells. In addition, these complexes were able to intercalate into DNA, indicating the dual mechanism of action.
KW - Cisplatin
UR - http://www.scopus.com/inward/record.url?scp=85123901225&partnerID=8YFLogxK
U2 - 10.1021/acs.inorgchem.1c03314
DO - 10.1021/acs.inorgchem.1c03314
M3 - Article
C2 - 35029379
AN - SCOPUS:85123901225
VL - 61
SP - 2105
EP - 2118
JO - Inorganic Chemistry
JF - Inorganic Chemistry
SN - 0020-1669
IS - 4
ER -
ID: 35393352