Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane. / Salnikov, Oleg G.; Kovtunov, Kirill V.; Nikolaou, Panayiotis и др.
в: ChemPhysChem, Том 19, № 20, 19.10.2018, стр. 2621-2626.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Heterogeneous Parahydrogen Pairwise Addition to Cyclopropane
AU - Salnikov, Oleg G.
AU - Kovtunov, Kirill V.
AU - Nikolaou, Panayiotis
AU - Kovtunova, Larisa M.
AU - Bukhtiyarov, Valerii I.
AU - Koptyug, Igor V.
AU - Chekmenev, Eduard Y.
N1 - © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2018/10/19
Y1 - 2018/10/19
N2 - Hyperpolarized gases revolutionize functional pulmonary imaging. Hyperpolarized propane is a promising emerging contrast agent for pulmonary MRI. Unlike hyperpolarized noble gases, proton-hyperpolarized propane gas can be imaged using conventional MRI scanners with proton imaging capability. Moreover, it is non-toxic odorless anesthetic. Furthermore, propane hyperpolarization can be accomplished by pairwise addition of parahydrogen to propylene. Here, we demonstrate the feasibility of propane hyperpolarization via hydrogenation of cyclopropane with parahydrogen. 1H propane polarization up to 2.4 % is demonstrated here using 82 % parahydrogen enrichment and heterogeneous Rh/TiO2 hydrogenation catalyst. This level of polarization is several times greater than that obtained with propylene as a precursor under the same conditions despite the fact that direct pairwise addition of parahydrogen to cyclopropane may also lead to formation of propane with NMR-invisible hyperpolarization due to magnetic equivalence of nascent parahydrogen protons in two CH3 groups. NMR-visible hyperpolarized propane demonstrated here can be formed only via a reaction pathway involving cleavage of at least one C–H bond in the reactant molecule. The resulting NMR signal enhancement of hyperpolarized propane was sufficient for 2D gradient echo MRI of ∼5.5 mL phantom with 1×1 mm2 spatial resolution and 64×64 imaging matrix despite relatively low chemical conversion of cyclopropane substrate.
AB - Hyperpolarized gases revolutionize functional pulmonary imaging. Hyperpolarized propane is a promising emerging contrast agent for pulmonary MRI. Unlike hyperpolarized noble gases, proton-hyperpolarized propane gas can be imaged using conventional MRI scanners with proton imaging capability. Moreover, it is non-toxic odorless anesthetic. Furthermore, propane hyperpolarization can be accomplished by pairwise addition of parahydrogen to propylene. Here, we demonstrate the feasibility of propane hyperpolarization via hydrogenation of cyclopropane with parahydrogen. 1H propane polarization up to 2.4 % is demonstrated here using 82 % parahydrogen enrichment and heterogeneous Rh/TiO2 hydrogenation catalyst. This level of polarization is several times greater than that obtained with propylene as a precursor under the same conditions despite the fact that direct pairwise addition of parahydrogen to cyclopropane may also lead to formation of propane with NMR-invisible hyperpolarization due to magnetic equivalence of nascent parahydrogen protons in two CH3 groups. NMR-visible hyperpolarized propane demonstrated here can be formed only via a reaction pathway involving cleavage of at least one C–H bond in the reactant molecule. The resulting NMR signal enhancement of hyperpolarized propane was sufficient for 2D gradient echo MRI of ∼5.5 mL phantom with 1×1 mm2 spatial resolution and 64×64 imaging matrix despite relatively low chemical conversion of cyclopropane substrate.
KW - contrast agent
KW - cyclopropane
KW - hydrogenation
KW - hyperpolarization
KW - parahydrogen-induced polarization
KW - Protons
KW - Magnetic Resonance Spectroscopy
KW - Magnetic Resonance Imaging/methods
KW - Hydrogen/chemistry
KW - Hydrogenation
KW - Feasibility Studies
KW - Catalysis
KW - Cyclopropanes/chemistry
KW - LUNG
KW - MRI
KW - SOURCE XE-129 HYPERPOLARIZER
KW - HYDROGEN-INDUCED POLARIZATION
KW - PROPANE GAS
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - NMR SIGNAL ENHANCEMENT
KW - MAGNETIC-RESONANCE
KW - LIVED SPIN STATES
KW - NUCLEAR-POLARIZATION
UR - http://www.scopus.com/inward/record.url?scp=85052951382&partnerID=8YFLogxK
U2 - 10.1002/cphc.201800690
DO - 10.1002/cphc.201800690
M3 - Article
C2 - 30039565
AN - SCOPUS:85052951382
VL - 19
SP - 2621
EP - 2626
JO - ChemPhysChem
JF - ChemPhysChem
SN - 1439-4235
IS - 20
ER -
ID: 16481593