TY - JOUR

T1 - Heterogeneous Catalysis and Parahydrogen-Induced Polarization

AU - Pokochueva, Ekaterina V.

AU - Burueva, Dudari B.

AU - Salnikov, Oleg G.

AU - Koptyug, Igor V.

N1 - Funding Information: We thank RSF (grant no. 19‐13‐00047) for the support of MRI studies. E. V. P. is also grateful to Haldor Topsøe A/S Ph.D. program for financial support. O. G. S. thanks the Russian Foundation for Basic Research (grant 19‐33‐60045). Publisher Copyright: © 2021 Wiley-VCH GmbH Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/7/16

Y1 - 2021/7/16

N2 - Parahydrogen-induced polarization with heterogeneous catalysts (HET-PHIP) has been a subject of extensive research in the last decade since its first observation in 2007. While NMR signal enhancements obtained with such catalysts are currently below those achieved with transition metal complexes in homogeneous hydrogenations in solution, this relatively new field demonstrates major prospects for a broad range of advanced fundamental and practical applications, from providing catalyst-free hyperpolarized fluids for biomedical magnetic resonance imaging (MRI) to exploring mechanisms of industrially important heterogeneous catalytic processes. This review covers the evolution of the heterogeneous catalysts used for PHIP observation, from metal complexes immobilized on solid supports to bulk metals and single-atom catalysts and discusses the general visions for maximizing the obtained NMR signal enhancements using HET-PHIP. Various practical applications of HET-PHIP, both for catalytic studies and for potential production of hyperpolarized contrast agents for MRI, are described.

AB - Parahydrogen-induced polarization with heterogeneous catalysts (HET-PHIP) has been a subject of extensive research in the last decade since its first observation in 2007. While NMR signal enhancements obtained with such catalysts are currently below those achieved with transition metal complexes in homogeneous hydrogenations in solution, this relatively new field demonstrates major prospects for a broad range of advanced fundamental and practical applications, from providing catalyst-free hyperpolarized fluids for biomedical magnetic resonance imaging (MRI) to exploring mechanisms of industrially important heterogeneous catalytic processes. This review covers the evolution of the heterogeneous catalysts used for PHIP observation, from metal complexes immobilized on solid supports to bulk metals and single-atom catalysts and discusses the general visions for maximizing the obtained NMR signal enhancements using HET-PHIP. Various practical applications of HET-PHIP, both for catalytic studies and for potential production of hyperpolarized contrast agents for MRI, are described.

KW - heterogeneous catalysis

KW - hyperpolarization

KW - NMR spectroscopy

KW - parahydrogen

KW - single-site catalysts

UR - http://www.scopus.com/inward/record.url?scp=85106599102&partnerID=8YFLogxK

U2 - 10.1002/cphc.202100153

DO - 10.1002/cphc.202100153

M3 - Review article

C2 - 33969590

AN - SCOPUS:85106599102

VL - 22

SP - 1421

EP - 1440

JO - ChemPhysChem

JF - ChemPhysChem

SN - 1439-4235

IS - 14

ER -