Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Heterogeneity of brain ribosomal genes expression following positive fighting experience in male mice as revealed by RNA-Seq. / Smagin, Dmitry A.; Kovalenko, Irina L.; Galyamina, Anna G. и др.
в: Molecular Neurobiology, Том 55, № 1, 01.01.2018, стр. 390-401.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Heterogeneity of brain ribosomal genes expression following positive fighting experience in male mice as revealed by RNA-Seq
AU - Smagin, Dmitry A.
AU - Kovalenko, Irina L.
AU - Galyamina, Anna G.
AU - Orlov, Yuriy L.
AU - Babenko, Vladimir N.
AU - Kudryavtseva, Natalia N.
N1 - Publisher Copyright: © Springer Science+Business Media New York 2016.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes’ expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in five brain regions of male mice with long repeated experience of aggression accompanied by wins (winners). Downregulation of most Rps, Rpl, Mrps, and Mrpl genes was found in the midbrain raphe nuclei and striatum and upregulation- in the hippocampus and hypothalamus of the winners. There were no changes in ribosomal gene expression in the ventral tegmental area. The data allow considering the alteration in ribosomal gene expression as an animal model of ribosomal dysfunction developed under positive fighting experience in male mice.
AB - Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes’ expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in five brain regions of male mice with long repeated experience of aggression accompanied by wins (winners). Downregulation of most Rps, Rpl, Mrps, and Mrpl genes was found in the midbrain raphe nuclei and striatum and upregulation- in the hippocampus and hypothalamus of the winners. There were no changes in ribosomal gene expression in the ventral tegmental area. The data allow considering the alteration in ribosomal gene expression as an animal model of ribosomal dysfunction developed under positive fighting experience in male mice.
KW - Mice
KW - Mitochondrial pathology
KW - Mrpl genes
KW - Mrps genes
KW - Positive fighting experience
KW - Repeated aggression
KW - Ribosomopathies
KW - Rpl genes
KW - Rps genes
UR - http://www.scopus.com/inward/record.url?scp=85050460683&partnerID=8YFLogxK
U2 - 10.1007/s12035-016-0327-z
DO - 10.1007/s12035-016-0327-z
M3 - Article
AN - SCOPUS:85050460683
VL - 55
SP - 390
EP - 401
JO - Molecular Neurobiology
JF - Molecular Neurobiology
SN - 0893-7648
IS - 1
ER -
ID: 15959570