TY - JOUR

T1 - Hepatic vascular changes associated with Opisthorchis felineus infection in Syrian hamsters and humans

AU - Kovner, Anna V

AU - Kapushchak, Yaroslav K

AU - Zaparina, Oxana

AU - Mordvinov, Viatcheslav A

AU - Pakharukova, Maria Y

N1 - We are thankful to Alexandra V. Gurova for valuable technical assistance. The microscopic analysis was conducted at the Microscopy Center of the ICG SB RAS (No. FWNR2022-0021). The English language was corrected by shevchuk-editing.com. Copyright © 2023. Published by Elsevier B.V.

PY - 2024/2

Y1 - 2024/2

N2 - The liver fluke Opisthorchis felineus is a foodborne zoonotic pathogen endemic to Russia, Kazakhstan, and several European countries. The adult flukes affect the hepatobiliary system of piscivorous mammals and humans, thereby causing numerous complications, including liver fibrosis. Detailing the mechanisms of progression of the fibrotic complications is a hot topic in the field of research on opisthorchiasis pathogenesis. Pathologic angiogenesis appears to be associated with the fibrogenic progression due to active participation in the recruitment of inflammatory cells and many factors involved in the modulation of the extracellular matrix. The aim of the study was to evaluate neoangiogenesis and amyloid deposits in liver tissues of model animals and patients with confirmed chronic opisthorchiasis. In addition, we assessed a possible correlation of neoangiogenesis with liver fibrosis. We found a significant increase in the number of newly formed vessels and amyloid deposits in the liver of people with chronic opisthorchiasis compared to that of uninfected ones. Thus, for the first time we have demonstrated neoangiogenesis and amyloid deposits during O. felineus infection in a Mesocricetus auratus model. Regression analysis showed that CD34+ newly formed vessels correlate with fibrosis severity in the course of the infection. Our results indicate the potential contribution of angiogenesis to the progression of liver fibrosis, associated with O. felineus infection.

AB - The liver fluke Opisthorchis felineus is a foodborne zoonotic pathogen endemic to Russia, Kazakhstan, and several European countries. The adult flukes affect the hepatobiliary system of piscivorous mammals and humans, thereby causing numerous complications, including liver fibrosis. Detailing the mechanisms of progression of the fibrotic complications is a hot topic in the field of research on opisthorchiasis pathogenesis. Pathologic angiogenesis appears to be associated with the fibrogenic progression due to active participation in the recruitment of inflammatory cells and many factors involved in the modulation of the extracellular matrix. The aim of the study was to evaluate neoangiogenesis and amyloid deposits in liver tissues of model animals and patients with confirmed chronic opisthorchiasis. In addition, we assessed a possible correlation of neoangiogenesis with liver fibrosis. We found a significant increase in the number of newly formed vessels and amyloid deposits in the liver of people with chronic opisthorchiasis compared to that of uninfected ones. Thus, for the first time we have demonstrated neoangiogenesis and amyloid deposits during O. felineus infection in a Mesocricetus auratus model. Regression analysis showed that CD34+ newly formed vessels correlate with fibrosis severity in the course of the infection. Our results indicate the potential contribution of angiogenesis to the progression of liver fibrosis, associated with O. felineus infection.

KW - Animals

KW - Cricetinae

KW - Humans

KW - Liver Cirrhosis/complications

KW - Mesocricetus

KW - Opisthorchiasis/epidemiology

KW - Opisthorchis

KW - Plaque, Amyloid/complications

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85180967250&origin=inward&txGid=536489c402f60c91dabf00b602e45758

UR - https://www.mendeley.com/catalogue/7f4564b7-7022-3eba-958c-cd09c6be1540/

U2 - 10.1016/j.actatropica.2023.107100

DO - 10.1016/j.actatropica.2023.107100

M3 - Article

C2 - 38101765

VL - 250

JO - Acta Tropica

JF - Acta Tropica

SN - 0001-706X

M1 - 107100

ER -