TY - JOUR

T1 - Guest Molecules Release from MOF-808 and MOF-Based Hydrogel: An EPR Study

AU - Yazikova, Anastasiya A.

AU - Tomilov, Aleksandr S.

AU - Livanovich, Kanstantsin S.

AU - Smirnova, Kristina A.

AU - Kirilyuk, Igor A.

AU - Polienko, Yuliya F.

AU - Poryvaev, Artem S.

AU - Fedin, Matvey V.

N1 - The research was funded by Russian Science Foundation (No. 24-43-10002) and Belarusian Republican Foundation for Fundamental Research (BRFFR, No. X23RNFM-048).

PY - 2025/11/27

Y1 - 2025/11/27

N2 - Precise, long-term control of drug concentration in organs and tissues of patients remains a significant challenge in modern pharmaceutics. In this work we investigate the metal–organic framework MOF-808, both in its pristine form and incorporated into a carboxymethylcellulose/chitosan (CMC-chitosan) hydrogel polyelectrolyte dressing, as a prospective platform for controlled drug release. Using electron paramagnetic resonance (EPR) spectroscopy and spin probes (radicals) that model drug molecules, we demonstrate that the controllable release kinetics from MOF-808 into water strongly depends on the functional groups of the released guests. The MOF-808 effectively functions as a reservoir, maintaining a stable target concentration of guest molecules in practical water volumes. Furthermore, embedding the MOF particles into CMC-chitosan hydrogel creates convenient platform for practical applications. Although conjugation of MOF-808 and hydrogel leads to an extra release of the cargo radicals, upon their elimination the release profile approaches that of the pristine MOF-808. This study underscores the potential of MOF-808 for sustained drug release applications and highlights critical considerations for its integration into composite hydrogel materials using EPR spectroscopy as the primary investigative tool.

AB - Precise, long-term control of drug concentration in organs and tissues of patients remains a significant challenge in modern pharmaceutics. In this work we investigate the metal–organic framework MOF-808, both in its pristine form and incorporated into a carboxymethylcellulose/chitosan (CMC-chitosan) hydrogel polyelectrolyte dressing, as a prospective platform for controlled drug release. Using electron paramagnetic resonance (EPR) spectroscopy and spin probes (radicals) that model drug molecules, we demonstrate that the controllable release kinetics from MOF-808 into water strongly depends on the functional groups of the released guests. The MOF-808 effectively functions as a reservoir, maintaining a stable target concentration of guest molecules in practical water volumes. Furthermore, embedding the MOF particles into CMC-chitosan hydrogel creates convenient platform for practical applications. Although conjugation of MOF-808 and hydrogel leads to an extra release of the cargo radicals, upon their elimination the release profile approaches that of the pristine MOF-808. This study underscores the potential of MOF-808 for sustained drug release applications and highlights critical considerations for its integration into composite hydrogel materials using EPR spectroscopy as the primary investigative tool.

UR - https://www.scopus.com/pages/publications/105024692948

UR - https://www.mendeley.com/catalogue/f36f368c-88e9-35a9-a9ce-fc48b92148ee/

U2 - 10.1021/acs.jpcc.5c06713

DO - 10.1021/acs.jpcc.5c06713

M3 - Article

VL - 129

SP - 21878

EP - 21886

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

SN - 1932-7447

IS - 49

ER -