TY - JOUR

T1 - Glycine: The Gift that Keeps on Giving

AU - Boldyreva, Elena

N1 - Funding Information: I would like to thank the Guest Editors of this Issue for the invitation to contribute. I thank also all my teachers and colleagues who assisted me throughout my scientific life and carreer for all their support, discussions, advises. I thank Dr. E. Losev and N. Bogdanov for technical support when preparing the figures for this manuscript. I thank Dr. A. Michalchuk for enormous assistance with the language polishing and formatting the references, as well as for many useful discussions. I acknowledge the financial support from Boreskov Institute of Catalysis while working on this manuscript (project AAAA‐A21‐121011390011‐4). Publisher Copyright: © 2021 Wiley-VCH GmbH

PY - 2021/12

Y1 - 2021/12

N2 - Glycine is a small molecule. It cannot change its conformation and is achiral. Despite the apparent simplicity, glycine shows endless diversity in its behavior over many phenomena. It was the first amino acid for which polymorphism was reported, first on crystallization and then on hydrostatic compression. The polymorphs differ in their physical properties and their biological activity. Glycine clusters persist in solution, leading to “solution memory”. Phenomena at interfaces are critically important for crystal growth, dissolution, and for physical properties, which can be at times unexpected, like polarity in centrosymmetric α-polymorph. It is a great pleasure to remind of these remarkable phenomena in a special issue honoring professors Meir Lahav and Leslie Leiserowitz, who pioneered the study of the behavior of this unique molecule in many respects, and showed how complex and non-trivial phenomena can be at interfaces: between phases and between research fields.

AB - Glycine is a small molecule. It cannot change its conformation and is achiral. Despite the apparent simplicity, glycine shows endless diversity in its behavior over many phenomena. It was the first amino acid for which polymorphism was reported, first on crystallization and then on hydrostatic compression. The polymorphs differ in their physical properties and their biological activity. Glycine clusters persist in solution, leading to “solution memory”. Phenomena at interfaces are critically important for crystal growth, dissolution, and for physical properties, which can be at times unexpected, like polarity in centrosymmetric α-polymorph. It is a great pleasure to remind of these remarkable phenomena in a special issue honoring professors Meir Lahav and Leslie Leiserowitz, who pioneered the study of the behavior of this unique molecule in many respects, and showed how complex and non-trivial phenomena can be at interfaces: between phases and between research fields.

KW - Biomedical applications

KW - Chirality

KW - Crystal growth

KW - High-pressure chemistry

KW - Interfaces

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=85118509664&partnerID=8YFLogxK

U2 - 10.1002/ijch.202100103

DO - 10.1002/ijch.202100103

M3 - Review article

AN - SCOPUS:85118509664

VL - 61

SP - 828

EP - 850

JO - Israel Journal of Chemistry

JF - Israel Journal of Chemistry

SN - 0021-2148

IS - 11-12

ER -