Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Genomic and Epidemiological Features of COVID-19 in the Novosibirsk Region during the Beginning of the Pandemic. / Palyanova, Natalia; Sobolev, Ivan; Alekseev, Alexander и др.
в: Viruses, Том 14, № 9, 2036, 09.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Genomic and Epidemiological Features of COVID-19 in the Novosibirsk Region during the Beginning of the Pandemic
AU - Palyanova, Natalia
AU - Sobolev, Ivan
AU - Alekseev, Alexander
AU - Glushenko, Alexandra
AU - Kazachkova, Evgeniya
AU - Markhaev, Alexander
AU - Kononova, Yulia
AU - Gulyaeva, Marina
AU - Adamenko, Lubov
AU - Kurskaya, Olga
AU - Bi, Yuhai
AU - Xin, Yuhua
AU - Sharshov, Kirill
AU - Shestopalov, Alexander
N1 - Funding Information: This research was funded by RFBR and NSFC, CNPq, DST according to the research project 20-54-80012 of BRICS STI Framework Programme. Additionally research was partially supported by RSF according to the research project 22-24-00199 and by the State funded budget project 122012400086-2. Publisher Copyright: © 2022 by the authors.
PY - 2022/9
Y1 - 2022/9
N2 - In this retrospective, single-center study, we conducted an analysis of 13,699 samples from different individuals obtained from the Federal Research Center of Fundamental and Translational Medicine, from 1 April to 30 May 2020 in Novosibirsk region (population 2.8 million people). We identified 6.49% positive for SARS-CoV-2 cases out of the total number of diagnostic tests, and 42% of them were from asymptomatic people. We also detected two asymptomatic people, who had no confirmed contact with patients with COVID-19. The highest percentage of positive samples was observed in the 80+ group (16.3%), while among the children and adults it did not exceed 8%. Among all the people tested, 2423 came from a total of 80 different destinations and only 27 of them were positive for SARS-CoV-2. Out of all the positive samples, 15 were taken for SARS-CoV-2 sequencing. According to the analysis of the genome sequences, the SARS-CoV-2 variants isolated in the Novosibirsk region at the beginning of the pandemic belonged to three phylogenetic lineages according to the Pangolin classification: B.1, B.1.1, and B.1.1.129. All Novosibirsk isolates contained the D614G substitution in the Spike protein, two isolates werecharacterized by an additional M153T mutation, and one isolate wascharacterized by the L5F mutation.
AB - In this retrospective, single-center study, we conducted an analysis of 13,699 samples from different individuals obtained from the Federal Research Center of Fundamental and Translational Medicine, from 1 April to 30 May 2020 in Novosibirsk region (population 2.8 million people). We identified 6.49% positive for SARS-CoV-2 cases out of the total number of diagnostic tests, and 42% of them were from asymptomatic people. We also detected two asymptomatic people, who had no confirmed contact with patients with COVID-19. The highest percentage of positive samples was observed in the 80+ group (16.3%), while among the children and adults it did not exceed 8%. Among all the people tested, 2423 came from a total of 80 different destinations and only 27 of them were positive for SARS-CoV-2. Out of all the positive samples, 15 were taken for SARS-CoV-2 sequencing. According to the analysis of the genome sequences, the SARS-CoV-2 variants isolated in the Novosibirsk region at the beginning of the pandemic belonged to three phylogenetic lineages according to the Pangolin classification: B.1, B.1.1, and B.1.1.129. All Novosibirsk isolates contained the D614G substitution in the Spike protein, two isolates werecharacterized by an additional M153T mutation, and one isolate wascharacterized by the L5F mutation.
KW - COVID-19
KW - epidemiology
KW - first wave
KW - phylogeny
KW - Russia
KW - SARS-CoV-2
KW - Genome, Viral
KW - Pandemics
KW - SARS-CoV-2/genetics
KW - Genomics
KW - Humans
KW - Phylogeny
KW - Spike Glycoprotein, Coronavirus/genetics
KW - COVID-19/epidemiology
KW - Adult
KW - Retrospective Studies
KW - Mutation
KW - Child
UR - http://www.scopus.com/inward/record.url?scp=85138403275&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/142b0815-14d3-3d43-87b5-01b8190e6bce/
U2 - 10.3390/v14092036
DO - 10.3390/v14092036
M3 - Article
C2 - 36146842
AN - SCOPUS:85138403275
VL - 14
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 9
M1 - 2036
ER -
ID: 38016007