Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Generation of two iPSC lines (ICGi008-A and ICGi008-B) from skin fibroblasts of a patient with early-onset Alzheimer's disease caused by London familial APP mutation (V717I). / Grigor'eva, E. V.; Malankhanova, T. B.; Ustyantseva, E. I. и др.
в: Stem Cell Research, Том 36, 101415, 01.04.2019.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Generation of two iPSC lines (ICGi008-A and ICGi008-B) from skin fibroblasts of a patient with early-onset Alzheimer's disease caused by London familial APP mutation (V717I)
AU - Grigor'eva, E. V.
AU - Malankhanova, T. B.
AU - Ustyantseva, E. I.
AU - Minina, J. M.
AU - Redina, O. E.
AU - Morozov, V. V.
AU - Shevela, A. I.
AU - Zakian, S. M.
AU - Medvedev, S. P.
N1 - Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - The induced pluripotent stem cell (iPSC) lines ICGi008-A and ICGi008-B were generated from dermal fibroblasts using episomal vectors expressing pluripotency factors. Dermal fibroblasts were obtained from a 55 year old male Сaucasian familial Alzheimer's disease (AD) patient carrying heterozygous V717I mutation in the APP gene. The generated iPSC lines maintained the original APP genotype, expressed pluripotency markers, exhibited a normal karyotype and retained the ability to differentiate into cell types of the three germ layers. The iPSC lines will be useful for the study of the AD molecular and cellular mechanisms and drug screening.
AB - The induced pluripotent stem cell (iPSC) lines ICGi008-A and ICGi008-B were generated from dermal fibroblasts using episomal vectors expressing pluripotency factors. Dermal fibroblasts were obtained from a 55 year old male Сaucasian familial Alzheimer's disease (AD) patient carrying heterozygous V717I mutation in the APP gene. The generated iPSC lines maintained the original APP genotype, expressed pluripotency markers, exhibited a normal karyotype and retained the ability to differentiate into cell types of the three germ layers. The iPSC lines will be useful for the study of the AD molecular and cellular mechanisms and drug screening.
UR - http://www.scopus.com/inward/record.url?scp=85062390628&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2019.101415
DO - 10.1016/j.scr.2019.101415
M3 - Article
C2 - 30851551
AN - SCOPUS:85062390628
VL - 36
JO - Stem Cell Research
JF - Stem Cell Research
SN - 1873-5061
M1 - 101415
ER -
ID: 18678460