Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Generation of a spinal muscular atrophy type III patient-specific induced pluripotent stem cell line ICGi003-A. / Ovechkina, V. S.; Maretina, M. A.; Egorova, A. A. и др.
в: Stem Cell Research, Том 48, 101938, 01.10.2020.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Generation of a spinal muscular atrophy type III patient-specific induced pluripotent stem cell line ICGi003-A
AU - Ovechkina, V. S.
AU - Maretina, M. A.
AU - Egorova, A. A.
AU - Baranov, V. S.
AU - Kiselev, A. V.
AU - Zakian, S. M.
AU - Valetdinova, K. R.
N1 - Funding Information: The reported study was funded by RFBR, project number 20-34-70019. Partial support from the Ministry of Science and Higher Education of the Russian Federation via D.O. Ott RIOG&R, project number AAAA-A19-119021290033-1 is also acknowleged. Publisher Copyright: © 2020 The Authors Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Spinal muscular atrophy (SMA) is a genetic disease, which characterized by the degeneration of motor neurons in the spinal cord and further striated muscle atrophy. The research of the processes in diseased neurons is complicated due to the impossibility of obtaining them safely from patients. Thus, we generated SMA type III induced pluripotent stem cell lines via using non-integrated episomal plasmid vectors. The resulting cell line expresses the major pluripotency markers and can differentiate in vitro into derivatives of three germ layers. The iPSC line can be used for further studies by providing in vitro the relevant cell types.
AB - Spinal muscular atrophy (SMA) is a genetic disease, which characterized by the degeneration of motor neurons in the spinal cord and further striated muscle atrophy. The research of the processes in diseased neurons is complicated due to the impossibility of obtaining them safely from patients. Thus, we generated SMA type III induced pluripotent stem cell lines via using non-integrated episomal plasmid vectors. The resulting cell line expresses the major pluripotency markers and can differentiate in vitro into derivatives of three germ layers. The iPSC line can be used for further studies by providing in vitro the relevant cell types.
UR - http://www.scopus.com/inward/record.url?scp=85089237348&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2020.101938
DO - 10.1016/j.scr.2020.101938
M3 - Article
C2 - 32795928
AN - SCOPUS:85089237348
VL - 48
JO - Stem Cell Research
JF - Stem Cell Research
SN - 1873-5061
M1 - 101938
ER -
ID: 24950836