TY - JOUR

T1 - Fucose ameliorates tryptophan metabolism and behavioral abnormalities in a mouse model of chronic colitis

AU - Borisova, Mariya A.

AU - Snytnikova, Olga A.

AU - Litvinova, Ekaterina A.

AU - Achasova, Kseniya M.

AU - Babochkina, Tatiana I.

AU - Pindyurin, Alexey V.

AU - Tsentalovich, Yuri P.

AU - Kozhevnikova, Elena N.

N1 - Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/2/11

Y1 - 2020/2/11

N2 - Growing evidence suggests that intestinal mucosa homeostasis impacts immunity, metabolism, the Central Nervous System (CNS), and behavior. Here, we investigated the effect of the monosaccharide fucose on inflammation, metabolism, intestinal microbiota, and social behavior in the Dextran Sulfate Sodium (DSS)-induced chronic colitis mouse model. Our data show that chronic colitis is accompanied by the decrease of the serum tryptophan level and the depletion of the intestinal microbiota, specifically tryptophan-producing E. coli and Bifidobacterium. These changes are associated with defects in the male mouse social behavior such as a lack of preference towards female bedding in an odor preference test. The addition of fucose to the test animals’ diet altered the bacterial community, increased the abundance of tryptophan-producing E. coli, normalized blood tryptophan levels, and ameliorated social behavior deficits. At the same time, we observed no ameliorating effect of fucose on colon morphology and colitis. Our results suggest a possible mechanism by which intestinal inflammation affects social behavior in male mice. We propose fucose as a promising prebiotic, since it creates a favorable environment for the beneficial bacteria that promote normalization of serum tryptophan level and amelioration of the behavioral abnormalities in the odor preference test.

AB - Growing evidence suggests that intestinal mucosa homeostasis impacts immunity, metabolism, the Central Nervous System (CNS), and behavior. Here, we investigated the effect of the monosaccharide fucose on inflammation, metabolism, intestinal microbiota, and social behavior in the Dextran Sulfate Sodium (DSS)-induced chronic colitis mouse model. Our data show that chronic colitis is accompanied by the decrease of the serum tryptophan level and the depletion of the intestinal microbiota, specifically tryptophan-producing E. coli and Bifidobacterium. These changes are associated with defects in the male mouse social behavior such as a lack of preference towards female bedding in an odor preference test. The addition of fucose to the test animals’ diet altered the bacterial community, increased the abundance of tryptophan-producing E. coli, normalized blood tryptophan levels, and ameliorated social behavior deficits. At the same time, we observed no ameliorating effect of fucose on colon morphology and colitis. Our results suggest a possible mechanism by which intestinal inflammation affects social behavior in male mice. We propose fucose as a promising prebiotic, since it creates a favorable environment for the beneficial bacteria that promote normalization of serum tryptophan level and amelioration of the behavioral abnormalities in the odor preference test.

KW - DSS-induced colitis

KW - Fucose

KW - Inflammation

KW - Microbiota

KW - Odor preference

KW - Tryptophan

KW - microbiota

KW - fucose

KW - RAT

KW - odor preference

KW - GUT MICROBIOTA

KW - MICROBIAL DYSBIOSIS

KW - inflammation

KW - INFLAMMATION

KW - FUCOIDAN

KW - TRACKING

KW - DISEASE

KW - SODIUM-INDUCED COLITIS

KW - STRESS

KW - EXPRESSION

KW - tryptophan

UR - http://www.scopus.com/inward/record.url?scp=85079334068&partnerID=8YFLogxK

U2 - 10.3390/nu12020445

DO - 10.3390/nu12020445

M3 - Article

C2 - 32053891

AN - SCOPUS:85079334068

VL - 12

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 2

M1 - 445

ER -