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From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis. / Svezhentseva, Ekaterina V.; Vorotnikov, Yuri A.; Solovieva, Anastasiya O. и др.

в: Chemistry - A European Journal, Том 24, № 68, 17.12.2018, стр. 17915-17920.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Svezhentseva, EV, Vorotnikov, YA, Solovieva, AO, Pozmogova, TN, Eltsov, IV, Ivanov, AA, Evtushok, DV, Miroshnichenko, SM, Yanshole, VV, Eling, CJ, Adawi, AM, Bouillard, JSG, Kuratieva, NV, Fufaeva, MS, Shestopalova, LV, Mironov, YV, Efremova, OA & Shestopalov, MA 2018, 'From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis', Chemistry - A European Journal, Том. 24, № 68, стр. 17915-17920. https://doi.org/10.1002/chem.201804663

APA

Svezhentseva, E. V., Vorotnikov, Y. A., Solovieva, A. O., Pozmogova, T. N., Eltsov, I. V., Ivanov, A. A., Evtushok, D. V., Miroshnichenko, S. M., Yanshole, V. V., Eling, C. J., Adawi, A. M., Bouillard, J. S. G., Kuratieva, N. V., Fufaeva, M. S., Shestopalova, L. V., Mironov, Y. V., Efremova, O. A., & Shestopalov, M. A. (2018). From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis. Chemistry - A European Journal, 24(68), 17915-17920. https://doi.org/10.1002/chem.201804663

Vancouver

Svezhentseva EV, Vorotnikov YA, Solovieva AO, Pozmogova TN, Eltsov IV, Ivanov AA и др. From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis. Chemistry - A European Journal. 2018 дек. 17;24(68):17915-17920. doi: 10.1002/chem.201804663

Author

Svezhentseva, Ekaterina V. ; Vorotnikov, Yuri A. ; Solovieva, Anastasiya O. и др. / From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis. в: Chemistry - A European Journal. 2018 ; Том 24, № 68. стр. 17915-17920.

BibTeX

@article{9104c1a554da4bef99935468a776ec13,
title = "From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis",
abstract = "Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.",
keywords = "cluster compounds, cytotoxicity, hydrolysis, molybdenum, tungsten, ONE-POT SYNTHESIS, ER STRESS, ENDOPLASMIC-RETICULUM STRESS, OXYGEN, NANOPARTICLES, POLYSTYRENE, COMPLEXES SYNTHESIS, HEXANUCLEAR MOLYBDENUM, LUMINESCENCE, GENERATION, Photosensitizing Agents/chemistry, Humans, Cell Survival/drug effects, Photochemical Processes, Light, Drug Stability, Models, Molecular, Neoplasms/drug therapy, Tungsten/chemistry, Molybdenum/chemistry, Antineoplastic Agents/chemistry, Hep G2 Cells, Hydrolysis, Cell Line, Tumor",
author = "Svezhentseva, {Ekaterina V.} and Vorotnikov, {Yuri A.} and Solovieva, {Anastasiya O.} and Pozmogova, {Tatiana N.} and Eltsov, {Ilia V.} and Ivanov, {Anton A.} and Evtushok, {Darya V.} and Miroshnichenko, {Svetlana M.} and Yanshole, {Vadim V.} and Eling, {Charlotte J.} and Adawi, {Ali M.} and Bouillard, {Jean Sebastien G.} and Kuratieva, {Natalia V.} and Fufaeva, {Maria S.} and Shestopalova, {Lidiya V.} and Mironov, {Yuri V.} and Efremova, {Olga A.} and Shestopalov, {Michael A.}",
note = "Publisher Copyright: {\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2018",
month = dec,
day = "17",
doi = "10.1002/chem.201804663",
language = "English",
volume = "24",
pages = "17915--17920",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "68",

}

RIS

TY - JOUR

T1 - From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis

AU - Svezhentseva, Ekaterina V.

AU - Vorotnikov, Yuri A.

AU - Solovieva, Anastasiya O.

AU - Pozmogova, Tatiana N.

AU - Eltsov, Ilia V.

AU - Ivanov, Anton A.

AU - Evtushok, Darya V.

AU - Miroshnichenko, Svetlana M.

AU - Yanshole, Vadim V.

AU - Eling, Charlotte J.

AU - Adawi, Ali M.

AU - Bouillard, Jean Sebastien G.

AU - Kuratieva, Natalia V.

AU - Fufaeva, Maria S.

AU - Shestopalova, Lidiya V.

AU - Mironov, Yuri V.

AU - Efremova, Olga A.

AU - Shestopalov, Michael A.

N1 - Publisher Copyright: © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2018/12/17

Y1 - 2018/12/17

N2 - Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.

AB - Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.

KW - cluster compounds

KW - cytotoxicity

KW - hydrolysis

KW - molybdenum

KW - tungsten

KW - ONE-POT SYNTHESIS

KW - ER STRESS

KW - ENDOPLASMIC-RETICULUM STRESS

KW - OXYGEN

KW - NANOPARTICLES

KW - POLYSTYRENE

KW - COMPLEXES SYNTHESIS

KW - HEXANUCLEAR MOLYBDENUM

KW - LUMINESCENCE

KW - GENERATION

KW - Photosensitizing Agents/chemistry

KW - Humans

KW - Cell Survival/drug effects

KW - Photochemical Processes

KW - Light

KW - Drug Stability

KW - Models, Molecular

KW - Neoplasms/drug therapy

KW - Tungsten/chemistry

KW - Molybdenum/chemistry

KW - Antineoplastic Agents/chemistry

KW - Hep G2 Cells

KW - Hydrolysis

KW - Cell Line, Tumor

UR - http://www.scopus.com/inward/record.url?scp=85056171211&partnerID=8YFLogxK

U2 - 10.1002/chem.201804663

DO - 10.1002/chem.201804663

M3 - Article

C2 - 30222219

AN - SCOPUS:85056171211

VL - 24

SP - 17915

EP - 17920

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 68

ER -

ID: 17408483