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First Evidence of Polymorphism in Furosemide Solvates. / Beloborodova, Alina A.; Minkov, Vasily S.; Rychkov, Denis A. и др.

в: Crystal Growth and Design, Том 17, № 5, 03.05.2017, стр. 2333-2341.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Beloborodova, AA, Minkov, VS, Rychkov, DA, Rybalova, TV & Boldyreva, EV 2017, 'First Evidence of Polymorphism in Furosemide Solvates', Crystal Growth and Design, Том. 17, № 5, стр. 2333-2341. https://doi.org/10.1021/acs.cgd.6b01191

APA

Beloborodova, A. A., Minkov, V. S., Rychkov, D. A., Rybalova, T. V., & Boldyreva, E. V. (2017). First Evidence of Polymorphism in Furosemide Solvates. Crystal Growth and Design, 17(5), 2333-2341. https://doi.org/10.1021/acs.cgd.6b01191

Vancouver

Beloborodova AA, Minkov VS, Rychkov DA, Rybalova TV, Boldyreva EV. First Evidence of Polymorphism in Furosemide Solvates. Crystal Growth and Design. 2017 май 3;17(5):2333-2341. doi: 10.1021/acs.cgd.6b01191

Author

Beloborodova, Alina A. ; Minkov, Vasily S. ; Rychkov, Denis A. и др. / First Evidence of Polymorphism in Furosemide Solvates. в: Crystal Growth and Design. 2017 ; Том 17, № 5. стр. 2333-2341.

BibTeX

@article{b757348568014c1a97558da5f91e798d,
title = "First Evidence of Polymorphism in Furosemide Solvates",
abstract = "Several polymorphs of solvates of furosemide with dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) have been obtained, and their crystal structures were solved and analyzed. The structures differ from each other in both conformation of the furosemide molecule (particularly with respect to the orientation of the furanylmethylamino fragment) and molecular packing. The arrangement of solvent molecules - DMSO and DMF - is different in different polymorphs: either in the channels or between the layers. Layered polymorphs can be formed on rapid crystallization using water as an antisolvent, whereas a slower crystallization on evaporation promotes the growth of channeled structures. Despite different crystal structures, F-DMSO-I, F-DMSO-II, F-DMSO-III, and F-DMF-II give the same phase on desolvation, namely, furosemide polymorph I, which is the thermodynamic form at ambient conditions.",
author = "Beloborodova, {Alina A.} and Minkov, {Vasily S.} and Rychkov, {Denis A.} and Rybalova, {Tatyana V.} and Boldyreva, {Elena V.}",
year = "2017",
month = may,
day = "3",
doi = "10.1021/acs.cgd.6b01191",
language = "English",
volume = "17",
pages = "2333--2341",
journal = "Crystal Growth and Design",
issn = "1528-7483",
publisher = "American Chemical Society",
number = "5",

}

RIS

TY - JOUR

T1 - First Evidence of Polymorphism in Furosemide Solvates

AU - Beloborodova, Alina A.

AU - Minkov, Vasily S.

AU - Rychkov, Denis A.

AU - Rybalova, Tatyana V.

AU - Boldyreva, Elena V.

PY - 2017/5/3

Y1 - 2017/5/3

N2 - Several polymorphs of solvates of furosemide with dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) have been obtained, and their crystal structures were solved and analyzed. The structures differ from each other in both conformation of the furosemide molecule (particularly with respect to the orientation of the furanylmethylamino fragment) and molecular packing. The arrangement of solvent molecules - DMSO and DMF - is different in different polymorphs: either in the channels or between the layers. Layered polymorphs can be formed on rapid crystallization using water as an antisolvent, whereas a slower crystallization on evaporation promotes the growth of channeled structures. Despite different crystal structures, F-DMSO-I, F-DMSO-II, F-DMSO-III, and F-DMF-II give the same phase on desolvation, namely, furosemide polymorph I, which is the thermodynamic form at ambient conditions.

AB - Several polymorphs of solvates of furosemide with dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) have been obtained, and their crystal structures were solved and analyzed. The structures differ from each other in both conformation of the furosemide molecule (particularly with respect to the orientation of the furanylmethylamino fragment) and molecular packing. The arrangement of solvent molecules - DMSO and DMF - is different in different polymorphs: either in the channels or between the layers. Layered polymorphs can be formed on rapid crystallization using water as an antisolvent, whereas a slower crystallization on evaporation promotes the growth of channeled structures. Despite different crystal structures, F-DMSO-I, F-DMSO-II, F-DMSO-III, and F-DMF-II give the same phase on desolvation, namely, furosemide polymorph I, which is the thermodynamic form at ambient conditions.

UR - http://www.scopus.com/inward/record.url?scp=85018979750&partnerID=8YFLogxK

U2 - 10.1021/acs.cgd.6b01191

DO - 10.1021/acs.cgd.6b01191

M3 - Article

AN - SCOPUS:85018979750

VL - 17

SP - 2333

EP - 2341

JO - Crystal Growth and Design

JF - Crystal Growth and Design

SN - 1528-7483

IS - 5

ER -

ID: 9049413