TY - JOUR

T1 - Extracellular microvesicular particles in the pathogenesis of tuberculosis

AU - Petrenko, S. E.

AU - Shvarts, Y. A.S.H.

AU - Belogorodtsev, S. N.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The review describes main classes of extracellular microvesicular particles, mechanisms of their biogenesis and their potential role in the development of tuberculosis. Special attention is paid to apoptosis of macrophages infected with tuberculous mycobacteria, generation of apoptotic ectosome and involvement of the latter into the formation of anti-tuberculosis immune response. Conclusion: mechanisms of apoptotic blebbing, ectosomes and clearing of these particles possess the potential to become a new tool within pathogenetic therapy of tuberculosis.

AB - The review describes main classes of extracellular microvesicular particles, mechanisms of their biogenesis and their potential role in the development of tuberculosis. Special attention is paid to apoptosis of macrophages infected with tuberculous mycobacteria, generation of apoptotic ectosome and involvement of the latter into the formation of anti-tuberculosis immune response. Conclusion: mechanisms of apoptotic blebbing, ectosomes and clearing of these particles possess the potential to become a new tool within pathogenetic therapy of tuberculosis.

KW - Apoptosis

KW - Apoptotic corpuscles

KW - Ectosomes

KW - Exosomes

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=85063646302&partnerID=8YFLogxK

U2 - 10.21292/2075-1230-2019-97-1-41-51

DO - 10.21292/2075-1230-2019-97-1-41-51

M3 - Article

AN - SCOPUS:85063646302

VL - 97

SP - 41

EP - 51

JO - Tuberculosis and Lung Diseases

JF - Tuberculosis and Lung Diseases

SN - 2075-1230

IS - 1

ER -