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Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution. / Burueva, Dudari B.; Romanov, Alexey S.; Salnikov, Oleg G. и др.
в: Journal of Physical Chemistry C, Том 121, № 8, 02.03.2017, стр. 4481-4487.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution
AU - Burueva, Dudari B.
AU - Romanov, Alexey S.
AU - Salnikov, Oleg G.
AU - Zhivonitko, Vladimir V.
AU - Chen, Yu Wen
AU - Barskiy, Danila A.
AU - Chekmenev, Eduard Y.
AU - Hwang, Dennis W.
AU - Kovtunov, Kirill V.
AU - Koptyug, Igor V.
PY - 2017/3/2
Y1 - 2017/3/2
N2 - Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d6 or methanol-d4). The approximate values of the HP decay time for propane dissolved in acetone-d6 are 35.1 and 28.6 s for the CH2 group and the CH3 group, respectively (similar values were obtained for propane dissolved in methanol-d4), which are ∼50 times larger than the gaseous propane T1 value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.
AB - Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d6 or methanol-d4). The approximate values of the HP decay time for propane dissolved in acetone-d6 are 35.1 and 28.6 s for the CH2 group and the CH3 group, respectively (similar values were obtained for propane dissolved in methanol-d4), which are ∼50 times larger than the gaseous propane T1 value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.
KW - PARAHYDROGEN-INDUCED POLARIZATION
KW - HYDROGEN-INDUCED POLARIZATION
KW - LIVED SPIN STATES
KW - IN-VIVO
KW - HETEROGENEOUS HYDROGENATION
KW - MAGNETIC-RESONANCE
KW - NMR
KW - MRI
KW - FIELD
KW - ENHANCEMENT
UR - http://www.scopus.com/inward/record.url?scp=85020384901&partnerID=8YFLogxK
U2 - 10.1021/acs.jpcc.7b00509
DO - 10.1021/acs.jpcc.7b00509
M3 - Article
C2 - 28286597
AN - SCOPUS:85020384901
VL - 121
SP - 4481
EP - 4487
JO - Journal of Physical Chemistry C
JF - Journal of Physical Chemistry C
SN - 1932-7447
IS - 8
ER -
ID: 10185886