Standard

Expression density of receptors to IL-1β in atopic dermatitis. / Alshevskaya, Alina A.; Lopatnikova, Julia A.; Krugleeva, Olga L. и др.

в: Molecular immunology, Том 75, 2016, стр. 92-100.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Alshevskaya, AA, Lopatnikova, JA, Krugleeva, OL, Nepomnyschih, VM, Lukinov, VL, Karaulov, AV & Sennikov, SS 2016, 'Expression density of receptors to IL-1β in atopic dermatitis', Molecular immunology, Том. 75, стр. 92-100. https://doi.org/10.1016/j.molimm.2016.05.015

APA

Alshevskaya, A. A., Lopatnikova, J. A., Krugleeva, O. L., Nepomnyschih, V. M., Lukinov, V. L., Karaulov, A. V., & Sennikov, S. S. (2016). Expression density of receptors to IL-1β in atopic dermatitis. Molecular immunology, 75, 92-100. https://doi.org/10.1016/j.molimm.2016.05.015

Vancouver

Alshevskaya AA, Lopatnikova JA, Krugleeva OL, Nepomnyschih VM, Lukinov VL, Karaulov AV и др. Expression density of receptors to IL-1β in atopic dermatitis. Molecular immunology. 2016;75:92-100. doi: 10.1016/j.molimm.2016.05.015

Author

Alshevskaya, Alina A. ; Lopatnikova, Julia A. ; Krugleeva, Olga L. и др. / Expression density of receptors to IL-1β in atopic dermatitis. в: Molecular immunology. 2016 ; Том 75. стр. 92-100.

BibTeX

@article{3cd6d1cf8464420bbf5e39417356c05a,
title = "Expression density of receptors to IL-1β in atopic dermatitis",
abstract = "Interleukin 1 (IL-1 β) and the system for regulation of its biological effects play an important role in the development and behavior of inflammatory processes in atopic dermatitis. Notably, cells that are actively involved in the pathological process have altered expression of cytokine receptors. However, standard evaluation of cells by flow cytometry measures only the percentage of cells expressing the appropriate marker, which is not enough for a full assessment of these changes. The aim of this study was to investigate changes in the expression of IL-1β cytokine receptors in patients with atopic dermatitis by both percentage of cells with receptors in various subsets and the absolute number of membrane-bound receptors themselves. It was found that an increase or decrease in the percentage of cells expressing the receptors in subsets of immune cells in patients with atopic dermatitis was not associated with a change in the number of receptors on the cell surface. Moreover, the changes in the percentage of cells and the number of receptors may occur in different directions, as shown for IL-1R2 expression on B cells and IL-1R1 expression for monocytes. Changes in the parameters of IL-1β receptor expressions are associated with disease severity index SCORAD in atopic dermatitis. These findings underline the importance of studying the density of cytokine receptor expression in the pathology.",
keywords = "Atopic dermatitis, Interleukin-1, Membrane-bound receptors, Receptor expression density",
author = "Alshevskaya, {Alina A.} and Lopatnikova, {Julia A.} and Krugleeva, {Olga L.} and Nepomnyschih, {Vera M.} and Lukinov, {Vitaliy L.} and Karaulov, {Aleksander V.} and Sennikov, {Sergey S.}",
note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2016",
doi = "10.1016/j.molimm.2016.05.015",
language = "English",
volume = "75",
pages = "92--100",
journal = "Molecular immunology",
issn = "0161-5890",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Expression density of receptors to IL-1β in atopic dermatitis

AU - Alshevskaya, Alina A.

AU - Lopatnikova, Julia A.

AU - Krugleeva, Olga L.

AU - Nepomnyschih, Vera M.

AU - Lukinov, Vitaliy L.

AU - Karaulov, Aleksander V.

AU - Sennikov, Sergey S.

N1 - Publisher Copyright: © 2016 Elsevier Ltd Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2016

Y1 - 2016

N2 - Interleukin 1 (IL-1 β) and the system for regulation of its biological effects play an important role in the development and behavior of inflammatory processes in atopic dermatitis. Notably, cells that are actively involved in the pathological process have altered expression of cytokine receptors. However, standard evaluation of cells by flow cytometry measures only the percentage of cells expressing the appropriate marker, which is not enough for a full assessment of these changes. The aim of this study was to investigate changes in the expression of IL-1β cytokine receptors in patients with atopic dermatitis by both percentage of cells with receptors in various subsets and the absolute number of membrane-bound receptors themselves. It was found that an increase or decrease in the percentage of cells expressing the receptors in subsets of immune cells in patients with atopic dermatitis was not associated with a change in the number of receptors on the cell surface. Moreover, the changes in the percentage of cells and the number of receptors may occur in different directions, as shown for IL-1R2 expression on B cells and IL-1R1 expression for monocytes. Changes in the parameters of IL-1β receptor expressions are associated with disease severity index SCORAD in atopic dermatitis. These findings underline the importance of studying the density of cytokine receptor expression in the pathology.

AB - Interleukin 1 (IL-1 β) and the system for regulation of its biological effects play an important role in the development and behavior of inflammatory processes in atopic dermatitis. Notably, cells that are actively involved in the pathological process have altered expression of cytokine receptors. However, standard evaluation of cells by flow cytometry measures only the percentage of cells expressing the appropriate marker, which is not enough for a full assessment of these changes. The aim of this study was to investigate changes in the expression of IL-1β cytokine receptors in patients with atopic dermatitis by both percentage of cells with receptors in various subsets and the absolute number of membrane-bound receptors themselves. It was found that an increase or decrease in the percentage of cells expressing the receptors in subsets of immune cells in patients with atopic dermatitis was not associated with a change in the number of receptors on the cell surface. Moreover, the changes in the percentage of cells and the number of receptors may occur in different directions, as shown for IL-1R2 expression on B cells and IL-1R1 expression for monocytes. Changes in the parameters of IL-1β receptor expressions are associated with disease severity index SCORAD in atopic dermatitis. These findings underline the importance of studying the density of cytokine receptor expression in the pathology.

KW - Atopic dermatitis

KW - Interleukin-1

KW - Membrane-bound receptors

KW - Receptor expression density

UR - http://www.scopus.com/inward/record.url?scp=84979247407&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2016.05.015

DO - 10.1016/j.molimm.2016.05.015

M3 - Article

C2 - 27267269

AN - SCOPUS:84979247407

VL - 75

SP - 92

EP - 100

JO - Molecular immunology

JF - Molecular immunology

SN - 0161-5890

ER -

ID: 27071690